Protein Alignment Hnf4 and Nr2c1

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_035759.3
• Gene: Nr2c1 / 22025
• MGIID: 1352465
• Length: 590
• Species: Mus musculus
• Alignment Length: 514
• Identity: 122/514 - (23%)
• Similarity: 205/514 - (39%)
• Gaps: 160/514 - (31%)

  Fly   135 NSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPT----VCAICGDRATGKHYGASSCDGCKGFFR 195
            |.:|..:.:||.      ...|.|.::...|.|.    :|.:|||:|:|:||||.:|:||||||:
Mouse    68 NQLFFTSPDLSA------PHLQLLTEKSPDQGPNKVFDLCVVCGDKASGRHYGAITCEGCKGFFK 126

  Fly   196 RSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDD---- 256
            ||:|||..|:||.:::||::|..||:|:||||::|...|||:::||.||..|...|..:.:
Mouse   127 RSIRKNLVYSCRGSKDCVINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAAS 191

  Fly   257 -------------------------------------------------------PDP------- 259
                                                                   ||.
Mouse   192 TEKIYIRKDLRSPLAATPTFVTDSETARSAGLLDSGMFVNIHPSGIKTEPAMLMAPDKAESCQGD 256

  Fly   260 -----------------------GNGLSVI----------------------------SLVKA-- 271
                                   |..:.|:                            :|.||
Mouse   257 LSTLASVVTSLANLGKAKDLSHCGGDMPVVQSLRNGDTSFGAFHHDIQTNGDVSRAFDTLAKALT 321

  Fly   272 --ENESRQSKAGA--------AMEPNINED----LSNK-------------QFASINDVCESMKQ 309
              |:.:.||....        |.||:..|.    ||..             ::.:::.:.||..:
Mouse   322 PGESSACQSPEEGMEGSPHLIAGEPSFVEKEGPLLSESHVAFRLTMPSPMPEYLNVHYIGESASR 386

  Fly   310 QLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSR--RSMHLKDVLLLSNNCVITRHCP 372
            .|...:.||..||:|..|..::.::|::|:..|...|||::  :.|::..:|....||:.:....
Mouse   387 LLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHSSLQQ 451

  Fly   373 DPLVSPNLDISRIGARI-IDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQI 436
            |.: ||....|.:.... :.|....|..:.||..|:|.:||:|.|.|:..||.....|:..:.:.
Mouse   452 DKM-SPERRKSLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELIERFQEKA 515

  Fly   437 LNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEML 495
            ....:|||:....:...|...:||.||.|:.:...:.|::.|..:.|...|||::..:|
Mouse   516 YVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHIL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	42/74 (57%)
		NR_LBD_HNF4_like	264..494	CDD:132729	65/289 (22%)
Nr2c1	NP_035759.3	Required for interaction with KAT2B	1..166		44/103 (43%)
		NR_DBD_TR2_like	96..182	CDD:143525	44/85 (52%)
		NR_LBD_TR2_like	355..576	CDD:132750	55/221 (25%)
		Required for interaction with NRIP1	571..590		1/4 (25%)