DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hnf4 and NR2F6

DIOPT Version :10

Sequence 1:NP_723413.1 Gene:Hnf4 / 44544 FlyBaseID:FBgn0004914 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_005225.2 Gene:NR2F6 / 2063 HGNCID:7977 Length:404 Species:Homo sapiens


Alignment Length:422 Identity:132/422 - (31%)
Similarity:214/422 - (50%) Gaps:62/422 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 GNAGSAGGGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTV---CAICGDRAT 178
            |..|..||.:............:.:::.|..|:.:::      :...::.|.:   |.:|||:::
Human     6 GGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDA------EPGDEERPGLQVDCVVCGDKSS 64

  Fly   179 GKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNE 243
            |||||..:|:|||.||:||:|:|..||||..|:|.:|:..||||:||||:|||:.||:|||||  
Human    65 GKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQ-- 127

  Fly   244 RDRI-----SCRRTSNDDPDPGNGLSVIS-----------------LVKAENESRQS-------- 278
            |.||     .....|:..| ||:.|:.::                 |::||.....:        
Human   128 RGRIPHSLPGAVAASSGSP-PGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGG 191

  Fly   279 KAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEH 343
            .|||.:              .|::|||...:.|.:.||||:..|.|.||.:.|||||||....|.
Human   192 AAGAVL--------------GIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSEL 242

  Fly   344 LLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFA 408
            .:|..::.::.|....||:   ....|.. |:.:..........|...|.|..:..:.:|..|:.
Human   243 FVLNAAQAALPLHTAPLLA---AAGLHAA-PMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYG 303

  Fly   409 CIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESR-GRFGEILLILPVLQSITWQM 472
            |:||:..|.|:|.||::|..::||:.:....|.:|:. .||.|: .|||.:||.||.|:::...:
Human   304 CLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVR-AQYPSQPQRFGRLLLRLPALRAVPASL 367

  Fly   473 IEQIQFAKIFGVAHIDSLLQEMLLGGELADNP 504
            |.|:.|.::.|...|::|:::|||.|...:.|
Human   368 ISQLFFMRLVGKTPIETLIRDMLLSGSTFNWP 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hnf4NP_723413.1 NR_DBD_HNF4A 170..245 CDD:143518 44/74 (59%)
NR_LBD_HNF4_like 264..494 CDD:132729 68/255 (27%)
NR2F6NP_005225.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49 6/48 (13%)
NR_DBD_COUP_TF 56..128 CDD:143516 44/73 (60%)
NR_LBD_COUP-TF 165..400 CDD:132746 73/254 (29%)
Important for dimerization. /evidence=ECO:0000250 327..404 25/74 (34%)

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