DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hnf4 and Rarg

DIOPT Version :10

Sequence 1:NP_723413.1 Gene:Hnf4 / 44544 FlyBaseID:FBgn0004914 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_035374.3 Gene:Rarg / 19411 MGIID:97858 Length:458 Species:Mus musculus


Alignment Length:480 Identity:126/480 - (26%)
Similarity:209/480 - (43%) Gaps:81/480 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 SAYPAASQPH--------SPIGLALSPNGGGLGLSNSSNQSSENFALCNGNGNAGSAGGGSASSG 130
            |.||.|..|.        ||....|||:..|||..:...:.:                       
Mouse    18 SGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMA----------------------- 59

  Fly   131 SNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTV---CAICGDRATGKHYGASSCDGCKG 192
                        :||.....|:|.:...........|.|   |.:|.|:::|.|||.|||:||||
Mouse    60 ------------SLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKG 112

  Fly   193 FFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDP 257
            |||||::||..|||...:||:::|..||:|:||||:|||:.||.||||:|:|::..........|
Mouse   113 FFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSP 177

  Fly   258 D-----PGNGLSVISLVKAENESRQS-------KAGAAMEPNINEDLSN-KQFASINDVCESMKQ 309
            |     |.....:..:.||..|:..|       ...::.:..:..||.. .:|:.:...|     
Mouse   178 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKC----- 237

  Fly   310 QLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDP 374
             ::.:||:||::|.|..|.:.||:.||:|...:.|:|.:..|....:|.:..|:...:.|     
Mouse   238 -IIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR----- 296

  Fly   375 LVSPNLDISRIGARIIDELVTV----MKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQ 435
                 ..:...|...:.:||..    :..:.:||||...:.|:.....:...|.||.::..|:..
Mouse   297 -----TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 356

  Fly   436 ILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGEL 500
            :|..|..|...|:......|..:|:.:..|:.|:.:..|:....|:.....:..|::|||...|:
Mouse   357 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 421

  Fly   501 --ADNPLPLSPPNQSNDYQSPTHTG 523
              .|:..|...|..|::.::|...|
Mouse   422 FEDDSSKPGPHPKASSEDEAPGGQG 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hnf4NP_723413.1 NR_DBD_HNF4A 170..245 CDD:143518 44/74 (59%)
NR_LBD_HNF4_like 264..494 CDD:132729 49/241 (20%)
RargNP_035374.3 Modulating 1..89 19/105 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 58..83 4/59 (7%)
NR_DBD_RAR 85..165 CDD:143522 45/79 (57%)
Hinge 156..184 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..180 4/18 (22%)
NR_LBD_RAR 188..418 CDD:132735 52/245 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..458 11/38 (29%)

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