Protein Alignment Hnf4 and Rara

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_033050.2
• Gene: Rara / 19401
• MGIID: 97856
• Length: 462
• Species: Mus musculus
• Alignment Length: 487
• Identity: 124/487 - (25%)
• Similarity: 215/487 - (44%)
• Gaps: 85/487 - (17%)

  Fly   112 LCNGNGNAGSAGGGSAS---------------SGSNNNNSMFSPNNNLSGSGSGT---------N 152
            :.:.:.:..:.|||..:               .|.:...::.|..:.|..||..|         :
Mouse     1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSLQHQLPVSGYSTPSPATIETQS 65

  Fly   153 SSQQQLQQQQQQQSP-----TVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNC 212
            ||.:::........|     ..|.:|.|:::|.|||.|:|:|||||||||::||..|||...:||
Mouse    66 SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNC 130

  Fly   213 VVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERD-------RISCRRTSNDDPDPGNGLSVISLVK 270
            :::|..||:|:||||:|||..||.||:|:|:|:       :..|..:....|:.|..:..:....
Mouse   131 IINKVTRNRCQYCRLQKCFDVGMSKESVRNDRNKKKKEAPKPECSESYTLTPEVGELIEKVRKAH 195

  Fly   271 AENESRQSKAGAAMEPNINE-------DLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQ 328
            .|......:.|.....|.:|       ||.:| |:.::..|      ::..||:|||:|.|..|.
Mouse   196 QETFPALCQLGKYTTNNSSEQRVSLDIDLWDK-FSELSTKC------IIKTVEFAKQLPGFTTLT 253

  Fly   329 LDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDEL 393
            :.||:.||:|...:.|:|.:..|....:|.:..|:...:.|          ..:...|...:.:|
Mouse   254 IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR----------TQMHNAGFGPLTDL 308

  Fly   394 VTVMKD----VGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGR 454
            |....:    :.:||.|...:.|:.....:.:.|.:|.::..|:..:|..|:.|:..|:......
Mouse   309 VFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEALKVYVRKRRPSRPHM 373

  Fly   455 FGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSPPNQSNDYQSP 519
            |.::|:.:..|:||:.:..|::...|:.....:..|:||||...|..|
Mouse   374 FPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLD----------------- 421

  Fly   520 THTGNMEGGNQVNSSL----DSLATSGGPGSH 547
            |.:|...||.:....|    .|.:.|..|.||
Mouse   422 TLSGQSGGGTRDGGGLAPPPGSCSPSLSPSSH 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	42/74 (57%)
		NR_LBD_HNF4_like	264..494	CDD:132729	51/240 (21%)
Rara	NP_033050.2	Modulating	1..87		12/85 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..77		4/24 (17%)
		NR_DBD_RAR	82..166	CDD:143522	43/83 (52%)
		Hinge	154..182		6/27 (22%)
		NR_LBD_RAR	186..416	CDD:132735	54/246 (22%)
		UBR5-degron. /evidence=ECO:0000250|UniProtKB:P10276	254..258		1/3 (33%)
		Required for binding corepressor NCOR1	404..419		5/14 (36%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P10276	408..416		5/7 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..462		11/51 (22%)