Protein Alignment Hnf4 and nhr-141

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001023845.2
• Gene: nhr-141 / 184926
• WormBaseID: WBGene00017787
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 431
• Identity: 90/431 - (20%)
• Similarity: 166/431 - (38%)
• Gaps: 106/431 - (24%)

  Fly   139 SPNNNLSGSGSGTNSSQQQLQQQQQQQS-------PTVCAICGDRATGKHYGASSCDGCKGFFRR 196
            |.:|..||.....|..|:....:..::|       ||.|::||.:|||.||...||:|||.||||
 Worm     5 SCSNIASGESLDLNWPQRLSDCKMSKESTFQRHPRPTECSVCGKKATGYHYDVPSCNGCKTFFRR 69

  Fly   197 SVRKNHQYTCRFARNCVVDKDKR---NQCRYCRLRKCFKAGMKKEAVQ-NERDRIS--------- 248
            .........|:...:| .|..||   .:||.||..||...||...|:| :|::..:
 Worm    70 ICISEKTMQCQGVGDC-FDLTKRIAPVKCRACRFEKCVLKGMNPNAMQIDEKEESAKNYKHLKKL 133

  Fly   249 ----CRRTSNDDPDPGNGLSVISLVKAENESRQSK---AGAAMEPNINE---DLSNKQFASI--- 300
                |::.|....:....::.|..:    |::..|   |.:.:|..:.:   ...|..:::|
 Worm   134 KNQYCQKDSEHSMEKKQTINSIDAI----ETKMQKLVDALSYLEIKLRKFRLSAYNPHWSTIPCL 194

  Fly   301 -------NDVCESMKQ---------------------------------------QLLTLVEWAK 319
                   |.:|.:.|.                                       .|:..:|:||
 Worm   195 EEFLLLENKICLADKSGPMPGWPLKTQPAPPKIPEFRNNPSGRPYFPDKKTWLLYDLMVSIEYAK 259

  Fly   320 QIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISR 384
            ....|::|...|::.|:|       .:.|:..::|:....:......|..  ||..::| ::...
 Worm   260 TFMFFHQLGTRDRLILMR-------YVSLALMNLHISYFTVAKKFDTIIH--PDGSLAP-MNKGM 314

  Fly   385 IGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSL---RHQILNNLEDYISD 446
            :.|..:..:..::: ..|.:.|:..:||:...:|....|: .|..|.|   |.|..:.|.|:...
 Worm   315 VYAETVMSMAPLIR-CNIQEIEYILLKAICLCNPAVPELS-THAQKILAKEREQYADALFDHCIR 377

  Fly   447 RQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHI 487
            .:.....:|.|::.::.:|:       .|.:..|...:.||
 Worm   378 SRTNGPAQFAELISMVDILE-------RQQRMQKDLHLLHI 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	33/78 (42%)
		NR_LBD_HNF4_like	264..494	CDD:132729	46/282 (16%)
nhr-141	NP_001023845.2	NR_DBD_HNF4A	43..119	CDD:143518	32/76 (42%)
		HOLI	249..399	CDD:214658	32/168 (19%)