Protein Alignment Hnf4 and nhr-118

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001317747.1
• Gene: nhr-118 / 184398
• WormBaseID: WBGene00003708
• Length: 363
• Species: Caenorhabditis elegans
• Alignment Length: 397
• Identity: 98/397 - (24%)
• Similarity: 170/397 - (42%)
• Gaps: 93/397 - (23%)

  Fly   158 LQQQQQQQSP----TVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDK 218
            ::|.:....|    :.|.:|||....:|||..||:|||||||||:.:...|.|.|...|.::...
 Worm     1 MEQSKMNVKPQPLVSACLVCGDPNIQRHYGTVSCNGCKGFFRRSIWEKRTYKCSFHNQCSIEHKY 65

  Fly   219 RNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDP----DPGNGLS-----VISLVKAEN- 273
            ||:||.|||.|||:|||...|::|:|.:   |::..:.|    .....||     :|:|:..:|
 Worm    66 RNRCRACRLEKCFRAGMDASAIRNKRAK---RKSQPESPCTEEIENRALSWQTEAIIALLMQKNG 127

  Fly   274 --ESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALL 336
              .::.|:...|.|.|    .|.:.|.:: :.....:.||...:.....:|.:..|
 Worm   128 QTHNKLSQFSGASEFN----FSTRSFVTL-ETLHLNRHQLPNRIWLENTLPEYQML--------- 178

  Fly   337 RAHAGEHLLLGLSRRSM------------------------HLKDVLLLS---NNCVITRHCPDP 374
             .||.:::|:.||..|:                        ..:|..|.|   :.||....|
 Worm   179 -VHADKNVLMSLSILSVCWLTSAFESYKFECDGILFADGSWFPRDRKLRSQVCSRCVTYFGC--- 239

  Fly   375 LVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPN-----------AKGLNEPHR 428
                .:|:      .:.::|..:|::.||:||...:||:....|:           |.|..:..:
 Worm   240 ----TVDL------FLTQVVYRIKELKIDETEITLLKAICHLQPSPQLSRHAIEIVANGQTKYKK 294

  Fly   429 IKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQE 493
            :  |...|.:|.:.|:     ::..|..:||.|||.|.::.....:......:.|: .:::..||
 Worm   295 V--LCEYIRSNTDGYM-----DASIRLCKILQILPELDALAKLEEDNGLLVSLSGI-ELNAARQE 351

  Fly   494 MLLGGEL 500
            :|.|..|
 Worm   352 VLPGNSL 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	37/74 (50%)
		NR_LBD_HNF4_like	264..494	CDD:132729	51/275 (19%)
nhr-118	NP_001317747.1	NR_DBD_HNF4A	17..91	CDD:143518	37/73 (51%)
		HOLI	167..324	CDD:214658	36/186 (19%)