Protein Alignment Hnf4 and nhr-149

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_504874.2
• Gene: nhr-149 / 182174
• WormBaseID: WBGene00015397
• Length: 375
• Species: Caenorhabditis elegans
• Alignment Length: 360
• Identity: 85/360 - (23%)
• Similarity: 142/360 - (39%)
• Gaps: 85/360 - (23%)

  Fly   169 VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKR-----NQCRYCRLR 228
            :|:||...|.|.||...||.|||.||||......:..|.....| .|.::|     ::||.||.:
 Worm     6 LCSICSRPAQGYHYDVISCKGCKTFFRRMWLSKIKEMCPLNNKC-FDFNRRINMSLSKCRACRFQ 69

  Fly   229 KCFKAGMKKEAVQ----NERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNIN 289
            :|...||...|:|    .::|....|...:.|....|.:..::.|:.:.|:.:.   :|..|.::
 Worm    70 RCLNVGMNPAAIQCDGNPKKDSSHFRDFDSIDEKIKNIIDTLTYVELKLENYRK---SAYNPVLS 131

  Fly   290 -----EDL------------------------------SNKQFASINDVCESMKQQ------LLT 313
                 :||                              |:.:..|..:.|....::      :||
 Worm   132 LSTGLDDLIEGSCSLSLAEIYGPMSGWPLGFEEHQLPSSSMRNVSCEEPCPVSNRKYWTHCNMLT 196

  Fly   314 LVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSN--NCVITRHCPDPLV 376
            .:|:.|....|:||...|:..|.|     |.|  |..:::|:....:..|  :|:    .||..:
 Worm   197 TIEYFKTFKFFHELSSRDKFVLAR-----HTL--LLCQNLHISHYTVSHNFDSCL----QPDGSM 250

  Fly   377 SPNLDISR--IGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNE-PHRIKSLRH---- 434
            .|..|...  |....|:.||...    |...|:..:||:.|.:|....|:: ..||.:...
 Worm   251 QPKQDERHYPIAMMSIEPLVRCK----IQHVEYVLLKAICFCNPAVPELSQNAQRILAKERYCFA 311

  Fly   435 QILNN--LEDYISDRQYESRGRFGEILLILPVLQS 467
            .||.|  |.:|.     :..|.|.|::.|..:|::
 Worm   312 DILINHCLRNYT-----DGPGHFAELIGIFNLLET 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	29/83 (35%)
		NR_LBD_HNF4_like	264..494	CDD:132729	52/256 (20%)
nhr-149	NP_504874.2	ZnF_C4	6..78	CDD:197701	27/72 (38%)
		HOLI	190..342	CDD:214658	43/172 (25%)