Protein Alignment Hnf4 and nhr-148

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_504871.1
• Gene: nhr-148 / 182172
• WormBaseID: WBGene00015396
• Length: 370
• Species: Caenorhabditis elegans
• Alignment Length: 358
• Identity: 89/358 - (24%)
• Similarity: 137/358 - (38%)
• Gaps: 88/358 - (24%)

  Fly   167 PTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQ----CRYCRL 227
            ||.|:||...|.|.||...||.|||.||||....|.|..|.....| .|..|.|:    ||.||.
 Worm     8 PTTCSICRRNAKGYHYDVISCKGCKTFFRRMSLINFQGKCDLNNQC-FDLTKANEPYLRCRACRY 71

  Fly   228 RKCFKAGMKKEAVQ----NE-------------------RDRISCRRTSNDDPDPGNGLSVISLV 269
            |||...||.::|:|    |:                   .:::...|.|.|:|. ...:|.:.|.
 Worm    72 RKCLDVGMNQKAIQIPERNQTFGVIETMTKNTIDALVYLEEKLEKFRLSADNPH-WQAVSDLELY 135

  Fly   270 --KAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQ------------------QLLTL 314
              ...|.....|.|...|.:::|....|     |.:..|:|.                  .|||.
 Worm   136 LNNGSNLGLADKFGPTFENSVHESFEPK-----NSLPSSLKAVQNNKLNHCPTKKIWTLCNLLTT 195

  Fly   315 VEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKD---------VLLLSNNCVITRH 370
            ||:.|....|.:|...|::.|.| |.   :|:|   :::|:.:         .|.:..:....||
 Worm   196 VEYLKTFNYFKDLSALDKLILAR-HV---ILIG---KNLHISNYSFSKKFTGCLNIETDAQRERH 253

  Fly   371 CPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHR--IKSLR 433
            .|            :...::..|:...    |...|:..:||:...:|....|::..:  :...|
 Worm   254 YP------------VAFMLMAPLIRSQ----IQPIEYILLKAICCCNPAVPNLSQKAQSTLARER 302

  Fly   434 HQILNNLEDYISDRQYESRGRFGEILLILPVLQ 466
            .|.::.|.||.........|||.|::.|..|::
 Worm   303 GQFVSILFDYCQRSGKNGPGRFAELIGIFSVME 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	35/101 (35%)
		NR_LBD_HNF4_like	264..494	CDD:132729	48/234 (21%)
nhr-148	NP_504871.1	ZnF_C4	10..80	CDD:197701	31/70 (44%)
		HOLI	191..337	CDD:214658	37/168 (22%)