Protein Alignment Hnf4 and nhr-1

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001024853.1
• Gene: nhr-1 / 181783
• WormBaseID: WBGene00003600
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 125/480 - (26%)
• Similarity: 205/480 - (42%)
• Gaps: 95/480 - (19%)

  Fly    69 ADALASAYPAASQPHSPIGLALSPNGGGLGLSNSSNQSSENFALCNGNGNAGSAG--GGSASSGS 131
            ||.|.|......||                :.||......:..:   ||:|.|..  .||:|.|
 Worm     6 ADQLQSHLANYGQP----------------MVNSQRNEDPSMYM---NGSAASVSHTNGSSSMG- 50

  Fly   132 NNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRR 196
              |:..|              .|.:::.|:::.....:||:|.|.|||.|||.:||:|||.||||
 Worm    51 --NDQKF--------------PSYKRMAQRRKVPEGELCAVCSDLATGYHYGVASCNGCKTFFRR 99

  Fly   197 SVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKE-----AVQNERDRISCRR----- 251
            ::.....:.|::..||.|:|:.|..||:||..||...||..:     |:||:||||...:
 Worm   100 TIVSEQTFICQYNGNCDVNKNIRCACRHCRFNKCLLVGMDAKALQIPAIQNDRDRIGPTKKIKMS 164

  Fly   252 TSNDD-----PDPGNGLSVI-SLVKAENESRQSK----------AGAAMEP---------NINED 291
            :.:||     |.......:| .|.:.|...::.:          ..|...|         .::..
 Worm   165 SGSDDEQATTPHRLQDQEIIDQLTQVEGLCQELRRCIIPEVTGVTHALTSPCLLFETTDLKVDVS 229

  Fly   292 LSNKQF-----ASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHA-GEHLLLGLSR 350
            |:|..|     ||:||:.....:::...:||||....:..|.|.||.||:|..| ..:||..:..
 Worm   230 LTNTIFKELFPASMNDIRMWNIREMRICIEWAKTFDVYQRLNLFDQFALVRNFAFAFNLLNRVFY 294

  Fly   351 RSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARII-----DELVTVMKDVGIDDTEFACI 410
            ...|..|.::..|...|.|       .|...:...|.|.|     ||::...:.:.:...|||..
 Worm   295 SPDHGPDKIVFQNGAFIMR-------QPQQQVQLSGCRPIYTRQMDEIMIPFRKLQLSVAEFATF 352

  Fly   411 KALVFFDPNAKGLN--EPHRIKSLRHQILNNLEDYISDRQYESRG--RFGEILLILPVLQSITWQ 471
            ||.:||:|:|..|:  ....:...|::.|..|...|:.:.....|  ::|.:|::...:|:|..|
 Worm   353 KAALFFNPDALDLSPQAKQEVFEERNKYLGGLFTCITQKIGIPTGVQKYGSLLMMTASIQNILAQ 417

  Fly   472 MIEQIQFAKIFGVAHIDSLLQEMLL 496
            ..|.:|..::|....:|..::|:.:
 Worm   418 NEENMQVMELFKNWEVDPFVKELCM 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	36/79 (46%)
		NR_LBD_HNF4_like	264..494	CDD:132729	61/264 (23%)
nhr-1	NP_001024853.1	NR_DBD_HNF4A	73..153	CDD:143518	36/79 (46%)
		HOLI	252..414	CDD:214658	43/168 (26%)