Protein Alignment Hnf4 and nhr-68

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001366648.1
• Gene: nhr-68 / 179589
• WormBaseID: WBGene00003658
• Length: 385
• Species: Caenorhabditis elegans
• Alignment Length: 397
• Identity: 101/397 - (25%)
• Similarity: 171/397 - (43%)
• Gaps: 79/397 - (19%)

  Fly   165 QSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRK 229
            ::..||.:|.|.::|.|||..||:|||.||||:|.|..::.|:|.:||.|||..|..||:||..|
 Worm     2 ENKEVCLVCQDFSSGYHYGIPSCNGCKTFFRRTVMKKQKFVCQFDQNCPVDKSIRCACRFCRFEK 66

  Fly   230 CFKAGMKKEAVQNERDRI--------SCRRTSND---------DPDP--------GNGLSVISL- 268
            |.|.||.|.::|..||.|        :.|...|:         .||.        .|.|:.:::
 Worm    67 CLKVGMDKTSLQASRDPIGYTKRNKKTLRHPMNELSGDESNSCTPDRQLSPLRSFENSLNFLAVR 131

  Fly   269 VKAENESRQS--------KAGAAMEPNINEDLSNKQFASINDVCESMKQQLLT------------ 313
            .::.||.|.|        |.....:|.||:.:...:.|:::......|.:.:|
 Worm   132 ERSANELRMSSYLPKRSLKQALCSKPLINDPIFMSKHATVSPRHTFEKLRFITQDDYHYWHERDW 196

  Fly   314 --LVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLV 376
              |.|:||....|..:...|:..|: .||.  :::.:..:..:..|..|            |.:|
 Worm   197 FVLTEYAKTFKVFKNMPYHDKTELV-CHAA--IVIPVLNQVYNSPDYGL------------DTVV 246

  Fly   377 SPN-------------LDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAK-GLNEPH 427
            .|:             ..::|...:::|.::...:::.|:..|||..||:.|.:|:|. .|...|
 Worm   247 FPDGTYYDRTHEPTRPAGLNRKKYQVLDLVLKPFREMEINFNEFAAFKAITFLNPDADISLESKH 311

  Fly   428 RIKSLRHQILNNLEDYI--SDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSL 490
            .|...|..|...|..|:  .|...::..|||.::|:...:..:..:..|.:..|..|......|.
 Worm   312 AINEERVLITKQLYAYMVQKDGLEKAIYRFGRLILMGTSMSKMACESKEAVWIADFFENIGFTSF 376

  Fly   491 LQEMLLG 497
            .:|::.|
 Worm   377 AKELIFG 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	37/74 (50%)
		NR_LBD_HNF4_like	264..494	CDD:132729	52/268 (19%)
nhr-68	NP_001366648.1	NR_DBD_HNF4A	7..82	CDD:143518	37/74 (50%)
		HOLI	193..354	CDD:214658	37/175 (21%)