Protein Alignment Hnf4 and nhr-101

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001041141.1
• Gene: nhr-101 / 179588
• WormBaseID: WBGene00003691
• Length: 391
• Species: Caenorhabditis elegans
• Alignment Length: 393
• Identity: 102/393 - (25%)
• Similarity: 168/393 - (42%)
• Gaps: 69/393 - (17%)

  Fly   165 QSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRK 229
            |...:|.:|.|.::|.|||..||:|||.||||::.|...:.|:..:||.|||..|..||:||..|
 Worm     2 QFEELCLVCNDLSSGYHYGVPSCNGCKTFFRRTIMKKQLFVCQHEKNCPVDKSIRCACRFCRFEK 66

  Fly   230 CFKAGMKKEAVQNERDRIS-CRRT-----------SNDDPDPGNGLS----------------VI 266
            |.:.||.|.|:|..||||. .:||           |:.:..||:..:                |:
 Worm    67 CIQVGMDKSALQASRDRIGYTKRTRKPKTKDVSFSSSSEMSPGSYFAESPGYAQKAFETYWSYVV 131

  Fly   267 SLVKAENESRQS--------KAGAAMEPNINEDL---------SNKQFASINDVCES-----MKQ 309
            |..||.||.|.|        |.....:..:|:.:         |...:.|:..:.::     .::
 Worm   132 SREKASNEMRLSDYLPKRSLKEALCSKSLLNDPIFLSKYALPSSKHTYTSLRFITQTDYHYWHER 196

  Fly   310 QLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSM------HLKDVLLLSNNCVIT 368
            ....|.|:||....|..|...|:..|:|     |..:.|...:.      |..|.::..:.....
 Worm   197 DWFVLTEYAKTFKIFEALSYADKAELVR-----HSAITLPALNQVYNSPDHGLDTVVFPDGTYYD 256

  Fly   369 R-HCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAK-GLNEPHRIKS 431
            | |.|   ..|: .::|...:::|.::...:::.|:..|||..||:.|.:|:|. .|.....|..
 Worm   257 RTHEP---TRPS-GLNRKKYQVLDLVLKPFREIDINFNEFAAFKAITFLNPDADVSLQAKLAINE 317

  Fly   432 LRHQILNNLEDYI--SDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEM 494
            .|..:...|.||:  :|...::..||..::||...:..:..:..|.:..|..|......|..:|:
 Worm   318 ERISVTKQLYDYMVRNDGIEKAIKRFSRLILIGTSMSKMACESKEAVWIADFFENIGYTSFAKEL 382

  Fly   495 LLG 497
            ..|
 Worm   383 FFG 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	35/74 (47%)
		NR_LBD_HNF4_like	264..494	CDD:132729	55/277 (20%)
nhr-101	NP_001041141.1	NR_DBD_HNF4A	7..82	CDD:143518	35/74 (47%)
		HOLI	195..356	CDD:214658	39/169 (23%)