Protein Alignment Hnf4 and nhr-47

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_504455.1
• Gene: nhr-47 / 178933
• WormBaseID: WBGene00003637
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 123/589 - (20%)
• Similarity: 204/589 - (34%)
• Gaps: 255/589 - (43%)

  Fly   168 TVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFK 232
            |:||:|.|.||||||..:||:|||.||||::..|.::.|:..::|.|:|..|..||||||:||..
 Worm     9 TLCAVCDDIATGKHYSVASCNGCKTFFRRALVNNREFVCQGNKDCPVNKGVRCACRYCRLQKCLA 73

  Fly   233 AGMKKEAVQNERDRI--SCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINED---- 291
            .||.|.::||:||||  :.|:..:||.|...|:         :.|...:.|::..|.:|::
 Worm    74 VGMDKNSIQNDRDRIGYTKRKRRHDDNDMEGGV---------HHSEHIRDGSSGSPQMNDESPES 129

  Fly   292 ----------------------LSNK------------QFASINDV------------CE----- 305
                                  |.|.            .:|::.|.            ||
 Worm   130 MDMKDIKIDLNCLDPIADRLTTLENNFTLLLSRCADLHSYATLEDALNAPSRFMQPISCEWSDNV 194

  Fly   306 ----------SMKQQLLTL-VEWAKQIPAFNELQLDDQVALLRAHAG------------EHLLLG 347
                      ..:|:|:.| ::|||....|..|...|:||::..||.            ||:...
 Worm   195 VLTNRDDKLPFWRQRLIALYIDWAKTFSTFRSLPYADKVAMVTNHASSFMIMCEAFRTPEHMKSD 259

  Fly   348 LSRRSMHLKDVL-----------------LLSNN--------------CV--------------- 366
            :.|:...|.:::                 |:||.              |:
 Worm   260 VVRKRPDLPNIVTSNSGSGCSRVSSVAGSLVSNGEDVHDDLTNLLHAACIQQSINKGIMFGENSS 324

  Fly   367 ---ITRHCP------DPLVSPNLD----------------------------------------- 381
               |..:.|      :||..|:.:
 Worm   325 DDKILLNLPIREIKKEPLEVPSTEGMIQLPTEYGNLPADYASWIPQDYGHPTAGHEGKSDMHNFF 389

  Fly   382 ----------------------ISRIGAR---------------------IIDELVTVMKDVGID 403
                                  :|.:.:|                     :||.::...:.:...
 Worm   390 EARDFCVGRPSSCNLNERSMKTVSMLESRNFQSPSANNSSLSGITPVLTMMIDLVMKPFRQLNFS 454

  Fly   404 DTEFACIKALVFFDPNAKGL------NEPHRIKSLRHQILNNLEDYISDRQYESRG---RFGEIL 459
            .||||.::|::||||:.:||      |.....|.|...:..:|:     :.|..:.   |:..|:
 Worm   455 TTEFALLQAIMFFDPDTEGLDSASQRNVVAEQKKLLAVLFRHLQ-----KAYNPQAASERYASII 514

  Fly   460 LILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSPPNQSNDYQSPTHTGN 524
            |.:|.::....:..|.:|...:..:..|:||::|..||            |..|| .|.....|.
 Worm   515 LRMPSIRRAAAKKNESLQVLDMLQMHEINSLVKETSLG------------PRPSN-VQQRMGIGG 566

  Fly   525 MEGG 528
            ..||
 Worm   567 GAGG 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	38/74 (51%)
		NR_LBD_HNF4_like	264..494	CDD:132729	65/455 (14%)
nhr-47	NP_504455.1	NR_DBD_HNF4A	11..86	CDD:143518	38/74 (51%)
		Hormone_recep	205..>260	CDD:459675	15/54 (28%)
		HOLI	<423..523	CDD:214658	22/104 (21%)