Protein Alignment Hnf4 and nhr-10

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_498554.1
• Gene: nhr-10 / 175993
• WormBaseID: WBGene00003609
• Length: 395
• Species: Caenorhabditis elegans
• Alignment Length: 403
• Identity: 115/403 - (28%)
• Similarity: 188/403 - (46%)
• Gaps: 61/403 - (15%)

  Fly   144 LSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRF 208
            ::|.|..:|:|.|..:         ||.:|.|.:||.|||..||:|||.||||::.||..::|:|
 Worm     1 MTGGGPSSNNSSQPEE---------VCLVCSDISTGYHYGVPSCNGCKTFFRRTIMKNQTFSCQF 56

  Fly   209 ARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRIS-CRRT-------------------- 252
            ...|.|||..|..||:||..||.:.||.:.|:|..||.|. .:||
 Worm    57 QGKCPVDKSIRCACRHCRFEKCLQVGMDRNAIQQNRDPIGYTKRTRRYPPIKKVEASDECSPAMV 121

  Fly   253 SNDDPDPGNGLSVIS--------LVKAENESRQSKAGAAMEPNINED---------------LSN 294
            |.:|....|.|:::|        |..||....::...|.:...:..|               :::
 Worm   122 SENDRSEDNFLTLLSSTEQKCCALRLAEYMPSRTLIEAVVSDCLLTDEVFMAEHAILSPRHRVTS 186

  Fly   295 KQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEH-LLLGLSRRSMHLKDV 358
            .:||:.:|.....::....::||||.:|.|..|...|::||||..|..: .|:.:.....|..|.
 Worm   187 LRFANQSDYHYWHERDWFVMIEWAKTLPVFQSLPFTDKLALLRHSAITYPSLVHVFNSPDHGLDT 251

  Fly   359 LLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGL 423
            ::..:.....| .|:|  :..|..::...:::|:|:..|:.:.||.||||..||:.|.:|:|..:
 Worm   252 IVFPDGAYFDR-TPEP--TRPLGFNKKKYQMLDQLLKPMRSMEIDMTEFAAFKAIFFLNPDADDV 313

  Fly   424 --NEPHRIKSLRHQILNNLEDY-ISDRQYESRG-RFGEILLILPVLQSITWQMIEQIQFAKIFGV 484
              |....:...|..|.|.|..| :..:..|..| |||.:||:..||.::..:|.|.:..|..|..
 Worm   314 DSNAKKTLSDGRSAITNALYRYMVKKKGAEDAGDRFGRLLLLGTVLATMAVEMKEAVLVADFFDQ 378

  Fly   485 AHIDSLLQEMLLG 497
            ....:..:::|.|
 Worm   379 IQFSTFAKQLLFG 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	36/74 (49%)
		NR_LBD_HNF4_like	264..494	CDD:132729	62/257 (24%)
nhr-10	NP_498554.1	NR_DBD_HNF4A	18..93	CDD:143518	36/74 (49%)
		HOLI	200..359	CDD:214658	47/161 (29%)