Protein Alignment CG2841 and COBLL1

DIOPT Version :10

• Sequence 1: NP_001284821.1
• Gene: CG2841 / 44529
• FlyBaseID: FBgn0003159
• Length: 1239
• Species: Drosophila melanogaster
• Sequence 2: NP_001265387.1
• Gene: COBLL1 / 22837
• HGNCID: 23571
• Length: 1233
• Species: Homo sapiens
• Alignment Length: 1295
• Identity: 258/1295 - (19%)
• Similarity: 431/1295 - (33%)
• Gaps: 384/1295 - (29%)

  Fly    39 KSSTQLHHLSTDTDINETSQLEYNRITPVPAATSNAPFEQTFRITVLLPKDQLFVARLGARVPLS 103
            |.:|.:..|..:..|.:...|:..:.||:      .| |:|.|:.:...|.|..:.|:.....|.
Human   166 KPNTPIGMLEVEKVILKPKMLDKKKPTPI------IP-EKTVRVVINFKKTQKTIVRVSPHASLQ 223

  Fly   104 KLLSLVCDNKQLD------ADKYEFRSPVDASQVYSCESTIGTVGLSE-----------IRLCHK 151
            :|..::|...:.|      ...|:.:.|:|.::      ::..:||.|           :.:..|
Human   224 ELAPIICSKCEFDPLHTLLLKDYQSQEPLDLTK------SLNDLGLRELYAMDVNRATSVTVFSK 282

  Fly   152 SESYDNF----NPDVMHK---------FQRTGVARDSLSSSSDFSSSRHSKVTAKTPSPYSSSNS 203
            |...::.    |.|:|.:         |||:...||.               ||..|    ::..
Human   283 SSLQESCQISQNLDIMKEKENKGFFSFFQRSKKKRDQ---------------TASAP----ATPL 328

  Fly   204 LNSMDSTGMNYTRTPVVVPP--AKVLAPPPRKKRTAPRPPSQVCIPEQSVP-DIPAANSKSEPAY 265
            :|....|   :||:..:..|  :..|.....|||.||.||...   .|||| |:
Human   329 VNKHRPT---FTRSNTISKPYISNTLPSDAPKKRRAPLPPMPA---SQSVPQDL----------- 376

  Fly   266 AVIVKRPQLCMSTPNLSGPLELDCNGNGSKSPDEDSTDG--------HYATLDLKPPIAGGPEPT 322
            |.|.:||..|:                 .||...|.||.        ...:|.|....||...
Human   377 AHIQERPASCI-----------------VKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSS-- 422

  Fly   323 PRKRLLQIKKKTAPAPP---PDFQSGGDNISLASLPEPVTPTPNIPQPAPRITTP--LPIAPTAN 382
                 |:..|:.||:||   |..||  |..|..:..:||...|  |..|....:|  |....|.:
Human   423 -----LRRTKRKAPSPPSKIPPHQS--DENSRVTALQPVDGVP--PDSASEANSPEELSSPETFH 478

  Fly   383 PPLAQVNGNGNGSPNGNVSKVLLNRTP------TPEPRSLGSATEDDDNDTASKQADSGIGEPAP 441
            |        |..|.....:..|:..|.      ||| .::.|.|....:|.:.::.|.
Human   479 P--------GLSSQEQCTAPKLMEETSVFECPGTPE-AAITSLTSGISSDYSLEEIDE------- 527

  Fly   442 SPSVSPEPEAEKSQQESSSEDDEAIKVYNFKLCQTSKKPEPSAATLAELTALTAQDIEEEDNHVD 506
            ...:|..|:.|.......|:|   |...:..:..|.|....||  |...:...:|:..||    .
Human   528 KEELSEVPKVEAENISPKSQD---IPFVSTDIINTLKNDPDSA--LGNGSGEFSQNSMEE----K 583

  Fly   507 QPASITNGNLATPSSETSLTS--WNYLDPISPPPDFSDQQMQKRNAGSLSPGSPLDEIVDELATI 569
            |....|:|.  .|.|....||  ...:|.|             ||..||.|.   .|.|.:...|
Human   584 QETKSTDGQ--EPHSVVYDTSNGKKVVDSI-------------RNLKSLGPN---QENVVQNEII 630

  Fly   570 INQQRLDTLIKKQPDPQMVEIESAKPNRLANFSITTAKSTTRIGRADSFQAGASGGGTEVASSGR 634
            :..:..:..:|.......:.:|....|...:..:....:                  :|...:..
Human   631 VYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSN------------------SEAHETDT 677

  Fly   635 ALSHRSSSHVSLNKLEQNGIGLGQRRSSSELSIGESPSLQS---------------PEVIKTILN 684
            |:|:: .:|::.:.:....:.......:.:.:|..:||..|               .|.::|..|
Human   678 AISYK-ENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNN 741

  Fly   685 --SRKNSLAESGGSAST--PVTEQPKIIKQLES--LAKEQSSVDGVKDI------SSSRSEAS-- 735
              |.::|...|..|.:|  ....|..:|...|.  ..|:.....|..|:      ....|.||
Human   742 NISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYL 806

  Fly   736 ------QQSPTPVPKKSN----PGVEKPTSPTFRAVQEPYPSSPALQK--SSPAVQEQRTSPVER 788
                  :|...|.||.||    ..:.|....|::.|.   |.|..:.|  .|..::.:....:..
Human   807 KNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVP---PKSLEISKDWQSETIEYKDDQDMHA 868

  Fly   789 PSLPPAVKSVEEQAVSLHQKEIVVQKESP--PLESMKESFVIVSKMSPPAVKKVPD--------P 843
            .......::|:|.|:......|   .|||  ||.::|....:.::...|:....||        |
Human   869 LGKKHTHENVKETAIQTEDSAI---SESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKP 930

  Fly   844 FPKVEAVKEESSGNESSQSTITPPNTPATPVSPVNLRNPNNTMAEIEQSQRDEPAPSSKPLPTTY 908
            .||:            ::.|.|.|..|       ||...||    |.:|:....|.:::..|:::
Human   931 APKM------------TRDTGTAPFAP-------NLEEINN----ILESKFKSRASNAQAKPSSF 972

  Fly   909 RYSGPPSINFATWSERPKSTVAIKNEGDYIFGGAGKSQQLTSPPSKLTIGVASPILRMGIPQGKE 973
                     |....:|.        .|.|:...|.||..            |:|
Human   973 ---------FLQMQKRV--------SGHYVTSAAAKSVH------------AAP----------- 997

  Fly   974 YHVPITVKPLKDEILENQQQEKKEKPEVQELKDQEIEKESVSVKVKPKTPVKPVQKRIEKPLDQ- 1037
                                    .|..:||.::|.|::.:....:..:|:..:...:.:||.:
Human   998 ------------------------NPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEK 1038

  Fly  1038 -DQNSL-QNHSSTLPRPAKSNRFTLPAAQ-NNQMVSHLTMNSLPRPVSSLERNRPVEANPAPAPF 1099
             |.:.: |..:...|.|......|:||:| :.|.:..|.....|||.||          ..|:||
Human  1039 TDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSS----------SGPSPF 1093

  Fly  1100 GQSTLRRTGFKERMLAKEQQEQEQALRI-----------RVSVNE--SIPSSATAPKSPPESK-- 1149
            ..:.::|:    :..:||:.|...|..:           ..|||:  .||....:.|....:.
Human  1094 ALAVVKRS----QSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNE 1154

  Fly  1150 -----PAPPSISGYVALKSTKVEVKLQEPETKPVSL---------QVKLKPTVQPATTPS 1195
                 |.|.....:..::.:.:..:..:||....||         ..|||....|:.|.|
Human  1155 QNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVTIPSNTIS 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2841	NP_001284821.1	PHA03247	<222..559	CDD:223021	87/360 (24%)
		PTZ00449	<660..905	CDD:185628	61/295 (21%)
		PHA03247	<729..1186	CDD:223021	98/513 (19%)
COBLL1	NP_001265387.1	RBD	113..179	CDD:460485	3/12 (25%)
		Cobl	197..275	CDD:462810	16/83 (19%)
		PHA03247	<894..1131	CDD:223021	62/337 (18%)
		WH2_Wc_Cobl	1182..1207	CDD:409199	7/24 (29%)
		actin-binding sequence	1203..1206	CDD:409199	2/2 (100%)