DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo2 and Cont

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1007	Identity:	229/1007 - (22%)
Similarity:	369/1007 - (36%)	Gaps:	218/1007 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PRIIEHPMDTT--VPKN---DPFTFNCQAEGNPTPTIQWFKDGRELKTD----------TGSHRI 140
            |..::.|.|||  |.||   :..|.:|.|.|.|||:..|:   ||:..|          ....|.
  Fly   362 PYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWY---REVYVDDRLEYQKIDPLAQDRY 423

  Fly   141 MLPAGGLFFLKVIHSRRES-DAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTRVAQGE 204
            .:..|.|    :|:..::: |.|.|.|.|:|:||..||.:|.|...|:. ||.|:      ...|
  Fly   424 TISGGNL----IIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIM-EFNLK------RSAE 477

  Fly   205 VALME------CGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRYQCVV 263
            .:.|.      |..|:..|:.:..|.::.....:..::|:.:...|.|........|...|.|.|
  Fly   478 TSEMNWGKSIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTV 542

  Fly   264 KNVVGTRESATAFLKVHVRP--------FLIRGPQ--NQTAVVGSSVVFQCRIGGDPLPDVLWRR 318
            :.:|........|..:.|.|        |....|:  .:..|.|..:..:|...|.|:|...|.|
  Fly   543 QTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTR 607

  Fly   319 TASGGNMPLRR--VHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPPKFVIRPK 381
            .    .:||:|  ..:...|.|.:.:.|..|.|||:|...|....:..:..:.:...|:|.|..|
  Fly   608 Q----GLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLK 668

  Fly   382 NQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDG-RMEVTLTPEGR-----SVLSIA 440
            :.:.:...:|.|.|:|...|.....|            |::. |::.......|     :||:|.
  Fly   669 DMIKDYNSDVTFICEAFAIPDANYTW------------YKNAERLDPANINRDRYIIQDNVLTIK 721

  Fly   441 RFAREDSGKVVTCNALNAVG---SVSSRTVVSVDTQFELPPPIIEQGPV---NQTLPVKSIVVLP 499
            ...::....:..|.|.|.:.   |.:...|:|:...|:..|...|...|   |.|        :.
  Fly   722 FLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTT--------IV 778

  Fly   500 CRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNG-KSSWS 563
            |.....|.|:..|..||..|....|  |.:..:|.||||...| :|||:|||:|||:.| ..|.:
  Fly   779 CDPEAAPRPKFQWKKDGQVIGSGGH--RRILPSGTLTISPTSR-DDEGIYTCIASNQAGTDESHA 840

  Fly   564 GYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSL-VGYVIEMF 627
            ..:.|.     .|:|...|           ||.:...|:.  |.:..........| :.||.:..
  Fly   841 RVIVLQ-----EIRFIETP-----------PQRIVSKEHD--LIFLHCEAAFDELLDIAYVWKHN 887

  Fly   628 G---KNETDG-------WVAVGTRVQNTTFTQTGLLPGVNYFFLIRA-----ENSHGLSLPSPMS 677
            |   ||..||       |..:  .|.||:....|     :|..::::     .:...:|:.....
  Fly   888 GEVLKNNHDGTGRIIVDWNRL--TVHNTSMRDAG-----DYECVVKSAVNEISSKTSVSIEGAPG 945

  Fly   678 EPITVGTRYFNSGLDLSEARASL------LSGDVVELSNASVVDSTSMKLTWQIINGKYVEGFYV 736
            .|..|..      :.:|:.:|.:      .:|..:...|  ::..|:...||..::      .:|
  Fly   946 APGGVQV------IQISKTKAIIEWVDGSHNGRAIRYYN--ILGRTNWNRTWVNVS------THV 996

  Fly   737 YARQLPNPIVNNPAPVTSNTNPLLGSTSTSA------SASASASALIST---KPNIAAAGKRDGE 792
            .||::........|.|.:.|.......|.:|      ...::.|.:.||   ||.||       .
  Fly   997 QAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIA-------P 1054

  Fly   793 TNQSGGGAP--------TPL--------NTKYRMLTILNGG--------------GASSCTITGL 827
            .|..|||..        .||        ...|::...|.|.              |.:...|...
  Fly  1055 RNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLN 1119

  Fly   828 VQYTLYEFFIVPFYKSVEGKPSNSRIARTLEDVPSEAPYGMEALLLNSSAVFLKWKAPEL--KDR 890
            ..||.||..:.......:|..|...:..:.||:|..||....||..||:...:.|:..::  ::.
  Fly  1120 NYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENI 1184

  Fly   891 HGVLLNYHV-----IVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVG 950
            .|.|:.:.:     ..:..|:.:..||...|..:        :..|.....|.|.|.|.|.||.|
  Fly  1185 RGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWAL--------IVGLQPDTYYFVKVMAYNAAGEG 1241

  Fly   951 PYCVPATLRLDPITKRLDPFINQRYPINQDHV 982
                |.:.|.:..|.|..|    :.|.:..||
  Fly  1242 ----PESERFEERTYRKAP----QKPPSSVHV 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	35/109 (32%)
		I-set	91..184	CDD:254352	35/108 (32%)
		I-set	190..279	CDD:254352	18/94 (19%)
		Ig2_Robo	193..279	CDD:143201	16/91 (18%)
		I-set	283..370	CDD:254352	23/98 (23%)
		Ig	300..370	CDD:299845	18/71 (25%)
		Ig	388..>457	CDD:299845	14/74 (19%)
		I-set	479..561	CDD:254352	29/85 (34%)
		Ig	496..561	CDD:143165	25/65 (38%)
		FN3	588..681	CDD:238020	20/108 (19%)
		FN3	<817..856	CDD:238020	8/52 (15%)
		fn3	864..952	CDD:278470	22/94 (23%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	33/104 (32%)
		I-set	362..462	CDD:254352	34/106 (32%)
		Ig	466..559	CDD:299845	19/99 (19%)
		IG_like	584..657	CDD:214653	20/76 (26%)
		IGc2	586..645	CDD:197706	18/62 (29%)
		Ig	667..751	CDD:299845	17/95 (18%)
		IG_like	676..751	CDD:214653	16/86 (19%)
		IG_like	765..844	CDD:214653	30/89 (34%)
		Ig	773..844	CDD:299845	28/81 (35%)
		I-set	851..940	CDD:254352	19/108 (18%)
		Ig	866..944	CDD:299845	15/84 (18%)
		FN3	944..1043	CDD:238020	18/112 (16%)
		FN3	1053..1146	CDD:238020	18/99 (18%)
		fn3	1156..1244	CDD:278470	23/99 (23%)
		fn3	1259..1346	CDD:278470	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840