DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu1 and tufm

DIOPT Version :9

Sequence 1:	NP_001163144.1	Gene:	mEFTu1 / 44438	FlyBaseID:	FBgn0024556	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001013523.1	Gene:	tufm / 541378	ZFINID:	ZDB-GENE-050320-73	Length:	448	Species:	Danio rerio

Alignment Length:	465	Identity:	290/465 - (62%)
Similarity:	355/465 - (76%)	Gaps:	20/465 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LALRCSRRAMSSARMLRMAGATATSTACKDWQRNGLLAAPRTGNMQQYLREYANE-KKVFERTKP 81
            :|...|.||..||  |::...:...::.|      |.|.|.:      .|.:|.| ||||.|.||
Zfish     1 MAALVSVRACLSA--LQLTSPSLLHSSFK------LCAVPLS------RRNFAAEAKKVFARDKP 51

  Fly    82 HCNVGTIGHVDHGKTTLTAAITKVLADKQLAESKKYNEIDNAPEEKARGITINVAHVEYQTETRH 146
            |.|:||||||||||||||||||||||:...|..|.|.:|||||||||||||||.:||||.|..||
Zfish    52 HLNIGTIGHVDHGKTTLTAAITKVLAEAGGANYKSYEDIDNAPEEKARGITINASHVEYTTANRH 116

  Fly   147 YGHTDCPGHADYIKNMITGTAQMDGAILVVAATDGAMPQTREHMLLAKQIGIDHIVVFINKVDAA 211
            |.||||||||||:||||||||||||.|||||||||.|||||||:|||:|||:.|:||:|||.||.
Zfish   117 YAHTDCPGHADYVKNMITGTAQMDGCILVVAATDGQMPQTREHLLLARQIGVQHVVVYINKADAV 181

  Fly   212 DE-EMVDLVEMEIRELLTEMGYDGDKIPVVKGSALCALEDKSPEIGKEAILKLLQEVDSFIPTPV 275
            |: ||:||||:||||||||.||||:..|||.||||||||:|.||:|..:|:|||:.:|..||.|.
Zfish   182 DDKEMLDLVELEIRELLTEFGYDGENTPVVVGSALCALENKKPELGVNSIMKLLEVIDGHIPLPS 246

  Fly   276 RELDKPFLLPVENVYSIPGRGTVVTGRLERGVVKKGMECEFVGYNKVLKSTVTGVEMFHQILEEA 340
            |:||||||:||:.|||||||||||:|.|||||:|||.||||:|:|:..||.:||:||||:.|:.|
Zfish   247 RDLDKPFLMPVDGVYSIPGRGTVVSGTLERGVIKKGDECEFLGHNRCFKSIITGIEMFHKSLDRA 311

  Fly   341 QAGDQLGALVRGVKRDDIKRGMVMCKPGSVKALDQLEAQVYILSKDEGGRTKPFMSFIQLQMFSR 405
            :|||.:|||:||:||:|::|||||.||||::...::.||||||||:||||.|||.:.....|||.
Zfish   312 EAGDNMGALIRGLKREDVRRGMVMIKPGSIQPHQKIRAQVYILSKEEGGRHKPFFTNFTPIMFSL 376

  Fly   406 TWDCAVQVQ-IPDKEMVMPGEDTKLILRLIRPMVLEQGQRFTLRDGNLTLGTGVVTSTLPPLTES 469
            |||.|..|: :|.||||||||||.:.|.|.:||.|::||||||||||.|:|||:||..   ||.:
Zfish   377 TWDMACIVELLPGKEMVMPGEDTAVNLILRQPMALDKGQRFTLRDGNQTIGTGLVTDI---LTIT 438

  Fly   470 QRSELTEGKK 479
            :..:.|.|:|
Zfish   439 KDDKYTWGEK 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu1	NP_001163144.1	PRK00049	73..463	CDD:234596	271/391 (69%)
		EF_Tu	81..274	CDD:206671	144/193 (75%)
		EFTU_II	282..368	CDD:293898	57/85 (67%)
		mtEFTU_III	371..462	CDD:294005	55/91 (60%)
tufm	NP_001013523.1	PRK00049	42..435	CDD:234596	271/395 (69%)
		EF_Tu	51..245	CDD:206671	144/193 (75%)
		EFTU_II	253..339	CDD:293898	57/85 (67%)
		mtEFTU_III	342..434	CDD:294005	55/91 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594800
Domainoid	1	1.000	302	1.000	Domainoid score	I1374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2490
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1054
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D298219at33208
OrthoFinder	1	1.000	-	-		FOG0002097
OrthoInspector	1	1.000	-	-		oto41287
orthoMCL	1	0.900	-	-		OOG6_100780
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R370
SonicParanoid	1	1.000	-	-		X2038
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.930