DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu1 and tuf1

DIOPT Version :9

Sequence 1:	NP_001163144.1	Gene:	mEFTu1 / 44438	FlyBaseID:	FBgn0024556	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_595746.1	Gene:	tuf1 / 2540210	PomBaseID:	SPBC9B6.04c	Length:	439	Species:	Schizosaccharomyces pombe

Alignment Length:	439	Identity:	247/439 - (56%)
Similarity:	320/439 - (72%)	Gaps:	11/439 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 MAGATATSTACKDWQRNGL------LAAPRTGNMQQYLREYANEKKVFERTKPHCNVGTIGHVDH 93
            |..|.|||...:.:::|.|      .|:..........|.||:| |||.|.|||.|:||||||||
pombe     1 MNSAKATSLLFQGFRKNCLRLNRISFASGLINRFTVPARTYADE-KVFVRKKPHVNIGTIGHVDH 64

  Fly    94 GKTTLTAAITKVLADKQLAESKKYNEIDNAPEEKARGITINVAHVEYQTETRHYGHTDCPGHADY 158
            |||||||||||.|:|...|....|::||.|||||||||||:.|||||:|..|||.|.||||||||
pombe    65 GKTTLTAAITKCLSDLGQASFMDYSQIDKAPEEKARGITISSAHVEYETANRHYAHVDCPGHADY 129

  Fly   159 IKNMITGTAQMDGAILVVAATDGAMPQTREHMLLAKQIGIDHIVVFINKVDAADEEMVDLVEMEI 223
            |||||||.|.|||||:||:||||.|||||||:|||:|:|:..|||:|||||..:.:|::|||||:
pombe   130 IKNMITGAATMDGAIIVVSATDGQMPQTREHLLLARQVGVKQIVVYINKVDMVEPDMIELVEMEM 194

  Fly   224 RELLTEMGYDGDKIPVVKGSALCALEDKSPEIGKEAILKLLQEVDSFIPTPVRELDKPFLLPVEN 288
            ||||:|.|:|||..|:|.||||||||.:.||||..:|.||::.|||:|..|.|:.|.|||:.:|:
pombe   195 RELLSEYGFDGDNTPIVSGSALCALEGREPEIGLNSITKLMEAVDSYITLPERKTDVPFLMAIED 259

  Fly   289 VYSIPGRGTVVTGRLERGVVKKGMECEFVGYNKVLKSTVTGVEMFHQILEEAQAGDQLGALVRGV 353
            |:||.|||||||||:|||.:|||.|.|.|||...||:||||:|||.:.|:.|.|||..|.|:|.:
pombe   260 VFSISGRGTVVTGRVERGTLKKGAEIEIVGYGSHLKTTVTGIEMFKKQLDAAVAGDNCGLLLRSI 324

  Fly   354 KRDDIKRGMVMCKPGSVKALDQLEAQVYILSKDEGGRTKPFMSFIQLQMFSRTWDCAVQVQIPD- 417
            ||:.:||||::.:||:|....:.:|..|||:|:||||...|:...:.|::|||.|..|::..||
pombe   325 KREQLKRGMIVAQPGTVAPHQKFKASFYILTKEEGGRRTGFVDKYRPQLYSRTSDVTVELTHPDP 389

  Fly   418 ---KEMVMPGEDTKLILRLIRPMVLEQGQRFTLRDGNLTLGTGVVTSTL 463
               .:|||||::.::|..||.|:|:|:|||||:|:|..|:||.:||..|
pombe   390 NDSDKMVMPGDNVEMICTLIHPIVIEKGQRFTVREGGSTVGTALVTELL 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu1	NP_001163144.1	PRK00049	73..463	CDD:234596	234/393 (60%)
		EF_Tu	81..274	CDD:206671	132/192 (69%)
		EFTU_II	282..368	CDD:293898	49/85 (58%)
		mtEFTU_III	371..462	CDD:294005	41/94 (44%)
tuf1	NP_595746.1	PRK00049	42..439	CDD:234596	237/398 (60%)
		EF_Tu	52..245	CDD:206671	132/192 (69%)
		EFTU_II	253..339	CDD:293898	49/85 (58%)
		EFTU_III	343..434	CDD:294006	39/90 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	282	1.000	Domainoid score	I296
eggNOG	1	0.900	-	-		E1_COG0050
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2490
Inparanoid	1	1.050	484	1.000	Inparanoid score	I262
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002097
OrthoInspector	1	1.000	-	-		oto102056
orthoMCL	1	0.900	-	-		OOG6_100780
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R370
SonicParanoid	1	1.000	-	-		X2038
TreeFam	1	0.960	-	-
	12	11.850