DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu1 and Tufm

DIOPT Version :9

Sequence 1:	NP_001163144.1	Gene:	mEFTu1 / 44438	FlyBaseID:	FBgn0024556	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_766333.1	Gene:	Tufm / 233870	MGIID:	1923686	Length:	452	Species:	Mus musculus

Alignment Length:	461	Identity:	287/461 - (62%)
Similarity:	354/461 - (76%)	Gaps:	28/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MSSARMLRMAGATATSTACKDWQRNGLLAAPRTGNMQQYLREY-------------ANEKKVFER 78
            |::|.:||     ||.      :.:||.|:| |..:|..||..             ...||.:.|
Mouse     1 MAAATLLR-----ATP------RFSGLCASP-TPFLQGRLRPLKAPASPFLCRGLAVEAKKTYVR 53

  Fly    79 TKPHCNVGTIGHVDHGKTTLTAAITKVLADKQLAESKKYNEIDNAPEEKARGITINVAHVEYQTE 143
            .|||.|||||||||||||||||||||:||:...|:.|||.||||||||:|||||||.|||||.|.
Mouse    54 DKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTA 118

  Fly   144 TRHYGHTDCPGHADYIKNMITGTAQMDGAILVVAATDGAMPQTREHMLLAKQIGIDHIVVFINKV 208
            .|||.||||||||||:||||||||.:||.||||||.||.|||||||:|||||||::|:||::||.
Mouse   119 ARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLAKQIGVEHVVVYVNKA 183

  Fly   209 DAA-DEEMVDLVEMEIRELLTEMGYDGDKIPVVKGSALCALEDKSPEIGKEAILKLLQEVDSFIP 272
            ||. |.|||:|||:||||||||.||.|::.||:.||||||||.:.||:|.:::.|||..||::||
Mouse   184 DAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEQRDPELGVKSVQKLLDAVDTYIP 248

  Fly   273 TPVRELDKPFLLPVENVYSIPGRGTVVTGRLERGVVKKGMECEFVGYNKVLKSTVTGVEMFHQIL 337
            .|.|:||||||||||:|||||||||||||.||||::|||.|||.:|:||.:::.|||:||||:.|
Mouse   249 VPTRDLDKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECELLGHNKNIRTVVTGIEMFHKSL 313

  Fly   338 EEAQAGDQLGALVRGVKRDDIKRGMVMCKPGSVKALDQLEAQVYILSKDEGGRTKPFMSFIQLQM 402
            |.|:|||.|||||||:||:|::||:||.||||::...::|||||||||:||||.|||:|.....|
Mouse   314 ERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIQPHQKVEAQVYILSKEEGGRHKPFVSHFMPVM 378

  Fly   403 FSRTWDCAVQVQI-PDKEMVMPGEDTKLILRLIRPMVLEQGQRFTLRDGNLTLGTGVVTSTLPPL 466
            ||.|||.|.:|.: |.||:.|||||.||.|.|.:||:||:||||||||||.|:|||:||. :|.:
Mouse   379 FSLTWDMACRVILPPGKELAMPGEDLKLSLILRQPMILEKGQRFTLRDGNKTIGTGLVTD-VPAM 442

  Fly   467 TESQRS 472
            ||..::
Mouse   443 TEEDKN 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu1	NP_001163144.1	PRK00049	73..463	CDD:234596	270/391 (69%)
		EF_Tu	81..274	CDD:206671	140/193 (73%)
		EFTU_II	282..368	CDD:293898	60/85 (71%)
		mtEFTU_III	371..462	CDD:294005	57/91 (63%)
Tufm	NP_766333.1	PRK00049	47..439	CDD:234596	270/392 (69%)
		EF_Tu	56..250	CDD:206671	140/193 (73%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	64..71		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	105..109		3/3 (100%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	126..129		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	181..184		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	219..221		1/1 (100%)
		EFTU_II	258..344	CDD:293898	60/85 (71%)
		mtEFTU_III	347..439	CDD:294005	57/92 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849227
Domainoid	1	1.000	297	1.000	Domainoid score	I1461
eggNOG	1	0.900	-	-		E1_COG0050
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2490
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002097
OrthoInspector	1	1.000	-	-		oto95162
orthoMCL	1	0.900	-	-		OOG6_100780
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R370
SonicParanoid	1	1.000	-	-		X2038
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.820