DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu1 and HBS1

DIOPT Version :9

Sequence 1:	NP_001163144.1	Gene:	mEFTu1 / 44438	FlyBaseID:	FBgn0024556	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	119/464 - (25%)
Similarity:	202/464 - (43%)	Gaps:	97/464 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QQYLREYANEKKVFERTKPHCNVGTIGHVDHGKTTL-------TAAITKVLADKQLAESKKYNE- 119
            |.|.:|.|::|.       |.::..|||||.||:||       |..:::.:..|...||||..:
  Fly   235 QLYEKERADQKS-------HIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQ 292

  Fly   120 -------IDNAPEEKARGITINVAHVEYQTETRHYGHTDCPGHADYIKNMITGTAQMDGAILVVA 177
                   :|...||:|||||::|.....:|:|:.....|.|||.|:|.|||:|..|.|.|:|||.
  Fly   293 SFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVD 357

  Fly   178 ATDGAMP-------QTREHMLLAKQIGIDHIVVFINKVDA---ADEEMVDLVEMEIRELLTEMGY 232
            ||.|...       |||||.:|.:.:|::.:.|.|||:|.   :.:...::| .:::..|...|:
  Fly   358 ATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTVGWSQDRFTEIV-TKLKSFLKLAGF 421

  Fly   233 DGDKIPVVKGSALCALEDKSPEIGKEAILK------LLQEVDSFIPTPVRELDKPFLLPVENVYS 291
            ....:.....|.|.. |:.:.:..:.|:..      ||..:::| ..|.|.:|:|..:.|.::|.
  Fly   422 KDSDVSFTPCSGLTG-ENLTKKAQEPALTNWYSGRHLLDVIENF-KIPERAIDRPLRMSVSDIYK 484

  Fly   292 IPGRGTVVTGRLERGVVKKGMECEFVGYNKVLKSTVTGVEMFHQILEEAQ--------------- 341
            ..|.|..::||:|.||:...        :|||    .|...     |:||
  Fly   485 GTGSGFCISGRVETGVLCLN--------DKVL----VGASR-----EQAQVKSLTMNEFPQTCVF 532

  Fly   342 AGDQLGALVRGVKRDDIKRGMVMCKPGS-VKALDQLEAQVYILSKDEGGRTKPFMSFIQLQMFSR 405
            ||||:...:..:..:::..|.::..|.: :....:.:|::.:.:.    :....|.|..|.....
  Fly   533 AGDQVSVTLPALDINNVTVGCIISDPQTPIPVTTRFQARIIVFNV----KVPITMGFPVLLHHQS 593

  Fly   406 TWDCAVQVQIPDKEMVMPGEDTK-------------LILRLIRPMVLEQGQ------RFTLRDGN 451
            ..:.||..::........||..|             :.|...||:.:|:..      |..||...
  Fly   594 LIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAG 658

  Fly   452 LTLGTGVVT 460
            :|:..|:||
  Fly   659 VTIAAGMVT 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu1	NP_001163144.1	PRK00049	73..463	CDD:234596	115/454 (25%)
		EF_Tu	81..274	CDD:206671	68/223 (30%)
		EFTU_II	282..368	CDD:293898	21/100 (21%)
		mtEFTU_III	371..462	CDD:294005	20/109 (18%)
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	116/458 (25%)
		EF1_alpha	249..468	CDD:206670	67/221 (30%)
		HBS1-like_II	474..557	CDD:293912	22/99 (22%)
		HBS1_C_III	561..669	CDD:294008	20/111 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464549
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840