Protein Alignment Shark and Jak1

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_445918.1
• Gene: Jak1 / 84598
• RGDID: 69056
• Length: 1153
• Species: Rattus norvegicus
• Alignment Length: 935
• Identity: 223/935 - (23%)
• Similarity: 339/935 - (36%)
• Gaps: 292/935 - (31%)

  Fly    86 TLVD-YYQQAANG---LPTKLTVPLIRDLPPHNTRS--HG------VTNLLHRATSKNESKV--- 135
            :||| |::..|:.   |.|.:..|||    .||.::  ||      ..|.|.:..|:....|
  Rat   407 SLVDGYFRLTADAHHYLCTDVAPPLI----VHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRW 467

  Fly   136 -------VFELLKC-----------GYRNFDAKNQDGQTALHLAALH--SDEDILKHLLNAKVQV 180
                   :...:.|           .::||..:.|.|:.:||.:..|  |..|::.||   |.|:
  Rat   468 SCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHL---KKQI 529

  Fly   181 NSSDSFG------CQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQE 239
            ..:|:..      |||       ||                |.|.|..|...:|         ||
  Rat   530 LRTDNISFVLKRCCQP-------KP----------------REISNLLVATKKA---------QE 562

  Fly   240 LLLAEAPPLPRTSSGEFPFD--LAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTL---TREEAV 299
            .       .|..|..:..||  |.|:..|   .|.|       ...||...|.|||   ..:|.:
  Rat   563 W-------QPVYSMSQLSFDRILKKDIIQ---GEHL-------GRGTRTHIYSGTLLDYKDDEGI 610

  Fly   300 AILKKHAKELLAKQP-EVDTSGCFLVRYSESPAASGLVLTLL---CDQVVKNFRISQADLYQNGN 360
            |..||....|....| ..|.|..|....|.....|...:..|   |.:.|:|..:.:
  Rat   611 AEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEE-------- 667

  Fly   361 KVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPK 425
                      :::.||.     .|..|  |.|..|....|:.|..|
  Rat   668 ----------FVEGGPL-----DLFMH--RKSDALTTPWKFKVAKQ------------------- 696

  Fly   426 AASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKG 490
            .||                    ||:..:.|...:.:.....|.|.                .:|
  Rat   697 LAS--------------------ALSYLEDKDLVHGNVCTKNLLLA----------------REG 725

  Fly   491 KRSD-------SESSVSGSLAGTEQELQAAAPML--------KSLSFSTEFSTFNADGVTGSGAA 540
            ..||       |:..:..|:. |.||.....|.:        |:||.:.:..:|   |.|.....
  Rat   726 IDSDIGPFIKLSDPGIPVSVL-TRQECIERIPWIAPECVEDSKNLSVAADKWSF---GTTLWEIC 786

  Fly   541 AAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKS----------DVAIERERAGQWIGNG--- 592
            ..||:               |:..||..|.|.|.:|          ::|....|...:..|.
  Rat   787 YNGEI---------------PLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPF 836

  Fly   593 YQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFI 657
            ::..|..::.|::|            .|:..:|.:                ..|||:....
  Rat   837 FRAIMRDINKLEEQ------------NPDIVSEKQ----------------PITEVDPTHF---- 869

  Fly   658 EPEKLVLD--REIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQ--EFLREASVMM 718
              ||..|.  |::|.|.||.|.   |.|....|:.:..:||:|.|..|.....  :..:|..::.
  Rat   870 --EKRFLKRIRDLGEGHFGKVE---LCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILR 929

  Fly   719 RLEHKCIVRLIGIAK---GEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYL 780
            .|.|:.||:..||..   |..:.::.|..|.||:.:|:..:.::|....:|| :|.||..||.||
  Rat   930 NLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLK-YAIQICKGMDYL 993

  Fly   781 ESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFS 845
            .|:.:|||||||||:|:.:.||.||.|||:::::......|........|:.|||||......|.
  Rat   994 GSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFY 1058

  Fly   846 HASDVWSFGVTIWEMFS--------------LGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYI 896
            .||||||||||:.|:.:              :..|.:|:::....:..:..|:||..|..||..:
  Rat  1059 IASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEV 1123

  Fly   897 YAVMQSCWKERPKDRPTFVYLTEFF 921
            |.:|:.||:.:|.:|.||..|.|.|
  Rat  1124 YQLMRKCWEFQPSNRTTFQNLIEGF 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	3/5 (60%)
		ANKYR	<94..317	CDD:440430	62/268 (23%)
		ANK repeat	124..151	CDD:293786	6/47 (13%)
		ANK repeat	153..184	CDD:293786	10/32 (31%)
		ANK repeat	186..217	CDD:293786	5/36 (14%)
		ANK repeat	220..245	CDD:293786	5/24 (21%)
		SH2_Cterm_shark_like	287..395	CDD:198211	25/114 (22%)
		PTKc_Syk_like	666..926	CDD:270650	93/275 (34%)
Jak1	NP_445918.1	FERM_F1	<52..129	CDD:465733
		FERM_F2	147..277	CDD:436450
		FERM_C_JAK1	282..426	CDD:275412	6/18 (33%)
		SH2_Jak1	426..526	CDD:198241	23/106 (22%)
		PTK_Jak1_rpt1	582..845	CDD:270662	69/371 (19%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	96/290 (33%)