Protein Alignment Shark and ZAP70

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_054188971.1
• Gene: ZAP70 / 7535
• HGNCID: 12858
• Length: 707
• Species: Homo sapiens
• Alignment Length: 928
• Identity: 223/928 - (24%)
• Similarity: 337/928 - (36%)
• Gaps: 361/928 - (38%)

  Fly     6 DP---MKWYHGNLSREAADELLK-QGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH--- 63
            ||   :.:::|::||..|:|.|| .|..||.||:|:...:.|.:||||:......|:.:.|.
Human    91 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 155

  Fly    64 -----GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNL 123
                 ||             |...|...|.::|.:..:|||..|..|
Human   156 TYAIAGG-------------KAHCGPAELCEFYSRDPDGLPCNLRKP------------------ 189

  Fly   124 LHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGC 188
            .:|.:.......||:.|:      ||
Human   190 CNRPSGLEPQPGVFDCLR------DA--------------------------------------- 209

  Fly   189 QPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSS 253
                         .:|..:.....::|                   ||:::.::::||
Human   210 -------------MVRDYVRQTWKLEG-------------------EALEQAIISQAP------- 235

  Fly   254 GEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDT 318
                 .:.|....||.|      ::|        |||.:||||||...|...|:          |
Human   236 -----QVEKLIATTAHE------RMP--------WYHSSLTREEAERKLYSGAQ----------T 271

  Fly   319 SGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEH 383
            .|.||:|..:....  ..|:|:..:.|.::.|||.   :.|......|:||     ...|..||:
Human   272 DGKFLLRPRKEQGT--YALSLIYGKTVYHYLISQD---KAGKYCIPEGTKF-----DTLWQLVEY 326

  Fly   384 LIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPT-PVSPHSHHQHPHV 447
            |...    :.||...||...|                |.....||.|..|| |..|.:
Human   327 LKLK----ADGLIYCLKEACP----------------NSSASNASGAAAPTLPAHPST------- 364

  Fly   448 PALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQA 512
                                  ||.|::.:
Human   365 ----------------------LTHPQRRI----------------------------------- 372

  Fly   513 AAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSD 577
                          .|.|:||.|
Human   373 --------------DTLNSDGYT------------------------------------------ 381

  Fly   578 VAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPST 642
                                            |..||:.|  |:......|.:.::......|.
Human   382 --------------------------------PEPARITS--PDKPRPMPMDTSVYESPYSDPE- 411

  Fly   643 PSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSD--EH 704
                |::..|| |......|:.|.|:|.|.||||..| :.:||      .:::||||:|..  |.
Human   412 ----ELKDKKL-FLKRDNLLIADIELGCGNFGSVRQGVYRMRK------KQIDVAIKVLKQGTEK 465

  Fly   705 SNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITAN--AELK 767
            ::.:|.:|||.:|.:|::..||||||:.:.|.||:|.|:|..|.:.::::....||..:  |||
Human   466 ADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL- 529

  Fly   768 VWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIR 832
              ..|::.||.|||.::||||||||||:||..||.|||||||:|::|....:.|.....|:||::
Human   530 --LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 592

  Fly   833 WYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIY 897
            |||||..|...||..|||||:|||:||..|.|..||.::...:.:..::.|:|:..|..||..:|
Human   593 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 657

  Fly   898 AVMQSCWKERPKDRPTFV 915
            |:|..||..:.:|||.|:
Human   658 ALMSDCWIYKWEDRPDFL 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	25/91 (27%)
		ANKYR	<94..317	CDD:440430	33/222 (15%)
		ANK repeat	124..151	CDD:293786	6/26 (23%)
		ANK repeat	153..184	CDD:293786	0/30 (0%)
		ANK repeat	186..217	CDD:293786	2/30 (7%)
		ANK repeat	220..245	CDD:293786	2/24 (8%)
		SH2_Cterm_shark_like	287..395	CDD:198211	30/107 (28%)
		PTKc_Syk_like	666..926	CDD:270650	109/255 (43%)
ZAP70	XP_054188971.1	SH2_N-SH2_Zap70_Syk_like	96..199	CDD:198191	32/133 (24%)
		SH2_C-SH2_Zap70	240..343	CDD:198265	38/140 (27%)
		PTKc_Zap-70	421..689	CDD:270686	111/264 (42%)