DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and YES1

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_005424.1 Gene:YES1 / 7525 HGNCID:12841 Length:543 Species:Homo sapiens


Alignment Length:546 Identity:143/546 - (26%)
Similarity:232/546 - (42%) Gaps:115/546 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   484 RKNKS---KGKRSDSESSVSGSLA--GTEQELQAAAPMLKSLSFSTEFSTFN------ADGVTGS 537
            ::|||   |.:..::...||.|::  |.|....:..|...:...:..||:.:      :.|||..
Human     7 KENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPF 71

  Fly   538 GAAAAGEVYNVPRNNTP--------IEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQW------ 588
            |.|::.  ::|..::.|        |.:.|.....:|..::.:.......|.....|.|      
Human    72 GGASSS--FSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSI 134

  Fly   589 -IG-NGYQPTMDV------------------------------------------------LSLL 603
             .| |||.|:..|                                                ||:.
Human   135 ATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIR 199

  Fly   604 D------QQIKAPAVARLNSLGPNASTESEMAS--------------YLHRKCSGTPSTPSATEV 648
            |      ..:|...:.:|::.|...:|.::..:              ..|:..:..|:....|: 
Human   200 DWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQ- 263

  Fly   649 EAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLR 712
            ..||..:.|..|.|.|:.::|.|.||.|..| |         ....:||||.|.......:.||:
Human   264 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW---------NGTTKVAIKTLKPGTMMPEAFLQ 319

  Fly   713 EASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGM 777
            ||.:|.:|.|..:|.|..:...|.:.:|.|....||:|.::.:...:.....:|...|:|||.||
Human   320 EAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGM 384

  Fly   778 HYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLG 842
            .|:|..:::||||.|.|||:......||:|||::|.:.  ..||...||.::||:|.|||:...|
Human   385 AYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYG 447

  Fly   843 IFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKER 907
            .|:..|||||||:...|:.:.|..||..:.|.:.::.|:.|.|:|.|..||..::.:|..|||:.
Human   448 RFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKD 512

  Fly   908 PKDRPTFVYLTEFF-----ARDPDYQ 928
            |.:||||.|:..|.     |.:|.||
Human   513 PDERPTFEYIQSFLEDYFTATEPQYQ 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 93/265 (35%)
YES1NP_005424.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45 10/37 (27%)
SH3_Yes 94..151 CDD:212940 12/56 (21%)
SH2_Src_family 154..253 CDD:199827 8/98 (8%)
PTKc_Yes 264..542 CDD:270654 102/286 (36%)
Blue background indicates that the domain is not in the aligned region.

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