Protein Alignment Shark and SRMS

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_543013.1
• Gene: SRMS / 6725
• HGNCID: 11298
• Length: 488
• Species: Homo sapiens
• Alignment Length: 261
• Identity: 93/261 - (35%)
• Similarity: 143/261 - (54%)
• Gaps: 13/261 - (4%)

  Fly   661 KLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKC 724
            :..|.|::|.|.||.|..| ||         ..|.||||::...:....:..:|...:..|.|:.
Human   229 EFALGRKLGEGYFGEVWEGLWL---------GSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHER 284

  Fly   725 IVRLIGIAK-GEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHR 788
            ::||..:.. ||.:.:|.||...|::..::............|..:|.|:|.||.|||.|..|||
Human   285 LIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHR 349

  Fly   789 DLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSF 853
            ||||||:|:......|::|||::|.|:  ...|..:...:.|::|.|||:.|..:||..||||||
Human   350 DLAARNVLVDDGLACKVADFGLARLLK--DDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSF 412

  Fly   854 GVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLT 918
            ||.:.|:|:.|..||..::|.:.::.:..|.|||:|..|||.:|.:|..||:..|::||:|..|.
Human   413 GVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLR 477

  Fly   919 E 919
            |
Human   478 E 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	92/256 (36%)
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780
		SH2	119..197	CDD:472789
		PTKc_Srm_Brk	223..483	CDD:133248	93/261 (36%)