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Protein Alignment Shark and SRC

DIOPT Version :10

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_047296363.1	Gene:	SRC / 6714	HGNCID:	11283	Length:	562	Species:	Homo sapiens

Alignment Length:	615	Identity:	171/615 - (27%)
Similarity:	255/615 - (41%)	Gaps:	146/615 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 GLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAAS--------------------PA--TPPTPV 436
            |.|.:|     |.|...:....|:..:..|||.||                    ||  ||..|.
Human     9 GAPAAL-----PVPVSSLSPARTMGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPA 68

  Fly   437 SPHSHH--QHPHVPALTITKKKQKENSSSMFNTLRLTSPKK------------ALFDMNSLRKNK 487
            |...|.  .....||....|.....|||.     .:|||::            ||:|..|..:..
Human    69 SADGHRGPSAAFAPAAAEPKLFGGFNSSD-----TVTSPQRAGPLAGGVTTFVALYDYESRTETD 128

  Fly   488 ---SKGKRSDSESSVSGS--LAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYN 547
               .||:|....::..|.  ||.               |.||        |.||          .
Human   129 LSFKKGERLQIVNNTEGDWWLAH---------------SLST--------GQTG----------Y 160

  Fly   548 VPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQP--TMDV----------- 599
            :|.|.      :.| :...:||..||.|    |.|..:.:.:.|...|  |..|
Human   161 IPSNY------VAP-SDSIQAEEWYFGK----ITRRESERLLLNAENPRGTFLVRESETTKGAYC 214

  Fly   600 LSLLD------QQIKAPAVARLNSLGPNASTESEMAS--------------YLHRKCSGTPSTPS 644
            ||:.|      ..:|...:.:|:|.|...::.::..|              ..||..:..|::..
Human   215 LSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 279

  Fly   645 ATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQ 708
            .|: ..||..:.|..|.|.|:.::|.|.||.|..| |         .....||||.|.....:.:
Human   280 QTQ-GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW---------NGTTRVAIKTLKPGTMSPE 334

  Fly   709 EFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQI 773
            .||:||.||.:|.|:.:|:|..:...|.:.:|.|....||:|.::.....:.....:|...|:||
Human   335 AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 399

  Fly   774 ACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPES 838
            |.||.|:|..::|||||.|.|||:......|::|||::|.:.  ..||...||.::||:|.|||:
Human   400 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEA 462

  Fly   839 FNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSC 903
            ...|.|:..|||||||:.:.|:.:.|..||..:.|.:.:..|:.|.|:|.|..||..::.:|..|
Human   463 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 527

  Fly   904 WKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            |::.|::||||.||..|.     :.:|.||
Human   528 WRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 557

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.