DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and BLK

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_011542126.1 Gene:BLK / 640 HGNCID:1057 Length:531 Species:Homo sapiens


Alignment Length:621 Identity:162/621 - (26%)
Similarity:251/621 - (40%) Gaps:179/621 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   397 VSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENS 461
            ||.|.|...:|..|.......|   :|..|.....||.|.....:|..|..|...:.:.|.    
Human     4 VSSKKPDKEKPIKEKDKGQWSP---LKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKH---- 61

  Fly   462 SSMFNTLRLTSPKKALFD---MNSLRKNKSKGKRSD----------SESSVSG------------ 501
               |..        ||:|   ||.......||::..          :.|.|:|            
Human    62 ---FVV--------ALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVAR 115

  Fly   502 ------------SLAGTEQELQAAAPMLKSLSFSTEFSTFN-------ADGVTGSG--------- 538
                        |....|.|.|..||:.|:.||....|..|       ...||..|         
Human   116 VESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR 180

  Fly   539 AAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLL 603
            ....|..|..||      |..|.:    :|.|::::|.             |:|          |
Human   181 CLDEGGYYISPR------ITFPSL----QALVQHYSKK-------------GDG----------L 212

  Fly   604 DQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREI 668
            .|::..|.|                        ...|..|.|.:      .:.|..:.|.|.|::
Human   213 CQRLTLPCV------------------------RPAPQNPWAQD------EWEIPRQSLRLVRKL 247

  Fly   669 GHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAK 733
            |.|:||.|..|:.        ::.::||||.|.:...:.:.||.||:||..|:|:.:|||..:..
Human   248 GSGQFGEVWMGYY--------KNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVT 304

  Fly   734 GEMLMMVQEL-----AP---------------------LGSMLQYI-LDHGHEITANAELKVWAS 771
            .|.:.:|.|.     ||                     .|.:|.:: .|.|..::. ..|...::
Human   305 KEPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKTDEGSRLSL-PRLIDMSA 368

  Fly   772 QIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAP 836
            |||.||.|:|..:.:||||.|.|||::.....||:|||::|.:   .:||...:|.::||:|.||
Human   369 QIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII---DSEYTAQEGAKFPIKWTAP 430

  Fly   837 ESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIY-AVM 900
            |:.:.|:|:..:|||||||.:.|:.:.|..||..:||.:.|:.::.|.|:|:|:.||..:| .|:
Human   431 EAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVI 495

  Fly   901 QSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            ..||:.||::||||.:    |.:|: |.:..|:..|
Human   496 AECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 98/292 (34%)
BLKXP_011542126.1 SH3_Blk 62..115 CDD:212942 11/60 (18%)
SH2_Src_Blk 120..219 CDD:198234 27/131 (21%)
Protein Kinases, catalytic domain 233..522 CDD:473864 100/300 (33%)
Blue background indicates that the domain is not in the aligned region.

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