Protein Alignment Shark and PTK6

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_005966.1
• Gene: PTK6 / 5753
• HGNCID: 9617
• Length: 451
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 138/425 - (32%)
• Similarity: 209/425 - (49%)
• Gaps: 63/425 - (14%)

  Fly   538 GAAAAGEVYNVPRNNTPIEIDLPPIAQK--TEAEVEYF---TKSDVAIERERAGQWIGN-----G 592
            ||.|.|   .||.|.         :|::  .|:|..:|   ::|:.....:..|...|.     .
Human    55 GAVAQG---YVPHNY---------LAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVS 107

  Fly   593 YQPTMD-VLSLLDQQ------IKAPAVARLNSLGPNASTES--EMASYLHRKCSGTPSTPSATEV 648
            .:|:.| |||:.|.|      |...|..||: |....|..|  |:.:| ||    ..|......:
Human   108 EKPSADYVLSVRDTQAVRHYKIWRRAGGRLH-LNEAVSFLSLPELVNY-HR----AQSLSHGLRL 166

  Fly   649 EAAKLRFFIEP-----------EKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLS 701
            .|...:...||           |:..|.|::|.|.||.|..| |         :.|::||||::|
Human   167 AAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLW---------KDRVQVAIKVIS 222

  Fly   702 DEHSNKQEFLR-EASVMMRLEHKCIVRLIGIAK-GEMLMMVQELAPLGSMLQYILDHGHEITANA 764
            .::...|:.|: |...|.:|.||.|:.|..:.. |:.:.::.||...||:|:.:.|...::...:
Human   223 RDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVS 287

  Fly   765 ELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRW 829
            ||...|.|:|.||.|||||:::||||||||||:......|:.|||::|.::   .:...:.....
Human   288 ELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIK---EDVYLSHDHNI 349

  Fly   830 PIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPA 894
            |.:|.|||:.:.|.:|..|||||||:.:.||||.|..||..:||.:|...||:|.|:|.|..||.
Human   350 PYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPP 414

  Fly   895 YIYAVMQSCWKERPKDRPTFVYLTEFFARDPDYQN 929
            .::.:|.:||...|:.||.|..|.|..:....|:|
Human   415 SVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYEN 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	98/262 (37%)
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781	7/25 (28%)
		SH2_PTK6_Brk	75..174	CDD:198221	25/104 (24%)
		Linker	171..190		2/18 (11%)
		PTKc_Srm_Brk	184..444	CDD:133248	100/271 (37%)