DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and btk

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_697087.6 Gene:btk / 568653 ZFINID:ZDB-GENE-070531-1 Length:640 Species:Danio rerio


Alignment Length:735 Identity:191/735 - (25%)
Similarity:295/735 - (40%) Gaps:206/735 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 GYVPLHEAAKHGNLEAVQ--ELLLAE--APPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPA 281
            |||         ::|.::  |::|.|  |||     ...:||.:..:.|..        |....:
Zfish    54 GYV---------DIEKIRCVEVVLPEDSAPP-----DRHYPFQIVYDEGPL--------YVFAKS 96

  Fly   282 NTTRDQWYHGTLTREEAVAILKKHAKELLAK-QPEVDTSGCFLVRYSESPAASGLVLTLLCDQVV 345
            :..|..|.|      |...:::.: |:|:.| .|      ||   :.:.       :...|.|.|
Zfish    97 DQIRKHWIH------ELKNVVRFN-KDLMQKYHP------CF---WEDG-------VWKCCLQEV 138

  Fly   346 KNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPE 410
            |                |:.|.:.|...:|          ..|.|.|...  ..:.|:||.|:.|
Zfish   139 K----------------QAMGCRVLETKNG----------GVFKRGSKNR--DSRKPLPPTPEEE 175

  Fly   411 VPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTI--TKKKQKENSSSMFNTLRLTSP 473
                        ||....|..||.|            ||.:|  |...:.|.:....|.|.|...
Zfish   176 ------------KPARPLPPEPPMP------------PAFSIGMTVIAEYEYAPMTTNDLELRKD 216

  Fly   474 KK----ALFDMNSLRKNKSKGKRSDSESS-VSGSLAGTEQ--------ELQAAAPMLKSLSFSTE 525
            ::    .:.|.|..:.....||.....|: :..:|.|.|:        ....|..:||       
Zfish   217 EEYTLLEISDPNWFKAKDKYGKEGYIPSNYIVQALNGLEKYDWYCKNINRSQAENLLK------- 274

  Fly   526 FSTFNADG---VTGSG-----------AAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKS 576
              |.|.||   |..||           ..|.||.....|:   ..|.|....|...||...||  
Zfish   275 --TENKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSCRH---YNILLTADGQFYLAEKHNFT-- 332

  Fly   577 DVAIERERAGQWIGNGYQPTMDVLSLLD--QQIKAPAVARLNSLGPNASTESEMASYLHRKCSGT 639
                                 ::..|::  |...|..|:||..:..|             :....
Zfish   333 ---------------------NIPELINYHQHNAAGLVSRLKYIVSN-------------RAQNA 363

  Fly   640 PSTPSATEVEAAKLRF---FIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKML 700
            |.|        |.|.:   .|:|.:|...||:|:|:||.|..| |         :.|.:|||||:
Zfish   364 PCT--------AGLGYGSWEIDPRQLTFIRELGNGQFGVVKYGKW---------QGRHDVAIKMV 411

  Fly   701 SDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILDHGHEITANA 764
            .:...::.:|:.||.|||:|.|..:|:|.|: .|...:.:|.|....|.:|.|:.:.....|:.|
Zfish   412 KEGSMSEDDFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQEGLLNPTSIA 476

  Fly   765 ELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRW 829
            .|:: ...::.||.|||:..|:||||||||.|:.:....|::|||:||.:.  ..||..:.|.::
Zfish   477 LLEM-CKDVSEGMKYLEANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVL--DDEYTSSVGSKF 538

  Fly   830 PIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPA 894
            |:||..||......||..||:|:|||.:||:::.|..||...:|.:.::.:.:|.||.:|.:...
Zfish   539 PVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANE 603

  Fly   895 YIYAVMQSCWKERPKDRPTF 914
            .::|:|.|||.|||.:||||
Zfish   604 NVFAIMNSCWHERPDERPTF 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430 22/100 (22%)
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786 7/27 (26%)
SH2_Cterm_shark_like 287..395 CDD:198211 20/108 (19%)
PTKc_Syk_like 666..926 CDD:270650 94/251 (37%)
btkXP_697087.6 None
Blue background indicates that the domain is not in the aligned region.

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