DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and grapa

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001018409.1 Gene:grapa / 553596 ZFINID:ZDB-GENE-050522-347 Length:214 Species:Danio rerio


Alignment Length:166 Identity:47/166 - (28%)
Similarity:74/166 - (44%) Gaps:43/166 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFS 71
            |..|:.|.:||..|:..|.| .:.|:||||||.:|.|:|.:|:.....|.|::|.: ..|..:| 
Zfish    57 PHAWFAGRISRHVAENRLHQ-RDCGSFLVRESESAPGEFSMSVSYGDHVQHFKVLK-DREGYYF- 118

  Fly    72 IDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDL-----------------PPHNTRSHG 119
                |..:|...|:.|||:|:  .|.:..:.|| .:|||                 |.||::.|.
Zfish   119 ----VWEEIFPSLNQLVDFYK--TNSIAKERTV-FLRDLDHTLKRPHHAHALFDFNPEHNSQLHF 176

  Fly   120 VTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQ 155
            :..            .|.:||.|.    |::...|:
Zfish   177 LRG------------DVIDLLDCS----DSQRWKGR 196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210 29/82 (35%)
ANKYR <94..317 CDD:440430 16/79 (20%)
ANK repeat 124..151 CDD:293786 5/26 (19%)
ANK repeat 153..184 CDD:293786 1/3 (33%)
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650
grapaNP_001018409.1 SH3 2..55 CDD:473055
SH2_Grb2_like 56..149 CDD:199828 34/101 (34%)
SH3_GRB2_like_C 159..211 CDD:212739 10/54 (19%)
Blue background indicates that the domain is not in the aligned region.

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