Protein Alignment Shark and Abl

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 734
• Identity: 163/734 - (22%)
• Similarity: 253/734 - (34%)
• Gaps: 266/734 - (36%)

  Fly   226 HEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQ------------------------ 266
            |....|.||||     |.::.|||...:|.....|..:|.:
  Fly   121 HPGKYHMNLEA-----LLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSS 180

  Fly   267 -TAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESP 330
             |:|.|            :..:|     |.:|          .|||..||.|....|:..|.
  Fly   181 TTSVFE------------SAHRW-----TSKE----------NLLAPGPEEDDPQLFVALYD--- 215

  Fly   331 AASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDG------PYWPSVEHLIAHFM 389
                                           .|:||...|.:..|      .|..|.|...||..
  Fly   216 -------------------------------FQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD 249

  Fly   390 RFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITK 454
            ..:.|.               |||              :..||...:..||.:..|
  Fly   250 SGNVGW---------------VPS--------------NYVTPLNSLEKHSWYHGP--------- 276

  Fly   455 KKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKS 519
                                        :.:|.::...|   |.::||....|.|   ::|..:|
  Fly   277 ----------------------------ISRNAAEYLLS---SGINGSFLVRESE---SSPGQRS 307

  Fly   520 LSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERER 584
            :|...|                 |.||:...:..|
  Fly   308 ISLRYE-----------------GRVYHYRISEDP------------------------------ 325

  Fly   585 AGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSL------------GPNASTESEMASYLHRKCS 637
                               |.::.....|:.|:|            |....|.....:....|.:
  Fly   326 -------------------DGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPT 371

  Fly   638 GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLS 701
            ..|.:|...|.|..:       ..:::..::|.|::|.|:.. |  ::.|.      .||:|.|.
  Fly   372 VFPLSPEPDEWEICR-------TDIMMKHKLGGGQYGEVYEAVW--KRYGN------TVAVKTLK 421

  Fly   702 DEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGE-MLMMVQELAPLGSMLQYILDHGHEITANAE 765
            ::....::||.||::|..::|..:|:|||:...| ...::.|....|::|.::...|.|......
  Fly   422 EDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVA 486

  Fly   766 LKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWP 830
            |...|:|||.||.||||::::||||||||.|:......|::|||::|.:|..:  |....|.::|
  Fly   487 LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDT--YTAHAGAKFP 549

  Fly   831 IRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAY 895
            |:|.|||......||..||||:|||.:||:.:.|..||..|...|....:|.|.|:.:|..||..
  Fly   550 IKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPE 614

  Fly   896 IYAVMQSCWKERPKDRPTF 914
            :|.:|:.||:....|||||
  Fly   615 VYDLMRQCWQWDATDRPTF 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430	24/115 (21%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786	7/18 (39%)
		SH2_Cterm_shark_like	287..395	CDD:198211	21/113 (19%)
		PTKc_Syk_like	666..926	CDD:270650	91/251 (36%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	16/116 (14%)
		SH2_ABL	268..363	CDD:198189	24/203 (12%)
		PTKc_Abl	382..644	CDD:270645	92/269 (34%)
		FABD	1584..1723	CDD:197885