DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and sev

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster


Alignment Length:1040 Identity:248/1040 - (23%)
Similarity:395/1040 - (37%) Gaps:296/1040 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LVR--ESSTAAGDFVLSLL-CQGEVCHYQVRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAA 95
            |:|  ..|...|...|:|: .||::|.|.|.|.....:..    :.|..:| |.|::.....|.:
  Fly  1572 LIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASAL----RAQLNLL-GEDSIAGQLAQDS 1631

  Fly    96 NGL----------------PTKLTVPL----IRDLPPHNTRSHGVTNLLHRATSKNESKVVFELL 140
            ..|                ..:.||.|    :|.|..||.:::...|.|...:|..      .||
  Fly  1632 GYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGG------SLL 1690

  Fly   141 KCGYRNFDAKNQDGQTALHLAALHSDEDI------LKHLLN---AKVQVNSSDSFGCQPL----- 191
            |.    .|.:.|  :..|||..:.:.||.      :::.||   ||...:.....|.:||     
  Fly  1691 KA----TDCEEQ--RCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLL 1749

  Fly   192 ---------------HYAARSKPASF------IRTLISAQANVQGRNIDNGYVPLHEAAKHGNLE 235
                           .|......:||      :.||:.|              ||          
  Fly  1750 GAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLA--------------PL---------- 1790

  Fly   236 AVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVA 300
               |||.|.|.|.|       |.:.:...  .:..|..::: |||.....:..|:....::|...
  Fly  1791 ---ELLTASATPSP-------PRNFSVRV--LSPRELEVSW-LPPEQLRSESVYYTLHWQQELDG 1842

  Fly   301 ILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSG 365
            ...:..:|..|.:..::|:|..  |.:.....||..|.:            ||    :....:|.
  Fly  1843 ENVQDRREWEAHERRLETAGTH--RLTGIKPGSGYSLWV------------QA----HATPTKSN 1889

  Fly   366 GSKFLYI------------DDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQP----KPEVPSF 414
            .|:.|::            :.|||                  .:||.:...|.|    :.|..|.
  Fly  1890 SSERLHVRSFAELPELQLLELGPY------------------SLSLTWAGTPDPLGSLQLECRSS 1936

  Fly   415 ATIPRSN------------MKPK-----------AASPATP---------------PT-PVSPHS 440
            |...|.|            ::|:           ||:|..|               |: |..|..
  Fly  1937 AEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQL 2001

  Fly   441 HHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAG 505
            .|....|..:|.|..:......:::|.       :||...:.:|:.:.:.:|:.     .|||  
  Fly  2002 EHIAEEVFRVTWTAARGNGAPIALYNL-------EALQARSDIRRRRRRRRRNS-----GGSL-- 2052

  Fly   506 TEQELQAAAPML---KSLSF--STEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQK 565
             ||...|..|::   :.|.|  :||.|.     :..|..::...::.|...:  :|....|.:::
  Fly  2053 -EQLPWAEEPVVVEDQWLDFCNTTELSC-----IVKSLHSSRLLLFRVRARS--LEHGWGPYSEE 2109

  Fly   566 TEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSL-------------------LDQQIKAPA 611
            :|...|.|      :..|:.|..:.....|...|.|.                   |.||.:...
  Fly  2110 SERVAEPF------VSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSI 2168

  Fly   612 VARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPE----KLVLDREIGHGE 672
            .:.|::|    .|:.::.:..:|..|.|.|     :.:.|.|     |:    :|.|.|.:|.|.
  Fly  2169 WSNLSTL----QTQQQLMAVRNRAFSTTLS-----DADIALL-----PQINWSQLKLLRFLGSGA 2219

  Fly   673 FGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIA-KGEM 736
            ||.|:.|.|  |:...||.: .||||.|....|...|.|:||.:|...:|:.||.|:||. ..|.
  Fly  2220 FGEVYEGQL--KTEDSEEPQ-RVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTES 2281

  Fly   737 LMMVQELAPLGSMLQYI------LDHGHEITAN---AELKVWASQIACGMHYLESQHFVHRDLAA 792
            :.::.|....|.:|.|:      .....:.||.   :||......:|.|..|||..||||||||.
  Fly  2282 ISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLAC 2346

  Fly   793 RNILLT-------ARHQAKISDFGMSRSLRPGSTEYQFTQG-GRWPIRWYAPESFNLGIFSHASD 849
            ||.|:|       .|...||.|||::|.:.  .::|...:| |..|:||.:|||...|:|:..||
  Fly  2347 RNCLVTESTGSTDRRRTVKIGDFGLARDIY--KSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSD 2409

  Fly   850 VWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            ||:|||..||:.:||..||...:|.:.:..|..|.||.||.:|...:|:::..||:..|.:||:|
  Fly  2410 VWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSF 2474

  Fly   915  914
              Fly  2475  2474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210 16/59 (27%)
ANKYR <94..317 CDD:440430 52/277 (19%)
ANK repeat 124..151 CDD:293786 6/26 (23%)
ANK repeat 153..184 CDD:293786 9/39 (23%)
ANK repeat 186..217 CDD:293786 9/56 (16%)
ANK repeat 220..245 CDD:293786 6/24 (25%)
SH2_Cterm_shark_like 287..395 CDD:198211 18/119 (15%)
PTKc_Syk_like 666..926 CDD:270650 100/267 (37%)
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 19/118 (16%)
FN3 1993..2111 CDD:238020 28/139 (20%)
PTKc_c-ros 2213..2483 CDD:270640 100/267 (37%)
Blue background indicates that the domain is not in the aligned region.

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