Protein Alignment Shark and ABL2

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 140/497 - (28%)
• Similarity: 220/497 - (44%)
• Gaps: 108/497 - (21%)

  Fly   450 LTITKKKQKE----NSSSMFNTLRLTS-----PKKALFDMNSLRKNK---SKGKRSDSE----SS 498
            |:|||.::..    |.:..::.:|..:     |...:..:|||.|:.   ....||.:|    |.
Human   126 LSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSL 190

  Fly   499 VSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIA 563
            ::||....|.|   ::|...|:|...|                 |.||:...|.|
Human   191 INGSFLVRESE---SSPGQLSISLRYE-----------------GRVYHYRINTT---------- 225

  Fly   564 QKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEM 628
                                                   .|.::...|.:|.::|.......|.:
Human   226 ---------------------------------------ADGKVYVTAESRFSTLAELVHHHSTV 251

  Fly   629 AS-------YLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKS 685
            |.       |...||    :.|:...|.....::.:|...:.:..::|.|::|.|:.| |
Human   252 ADGLVTTLHYPAPKC----NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW----- 307

  Fly   686 GAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGE-MLMMVQELAPLGSM 749
               ::..|.||:|.|.::....:|||:||:||..::|..:|:|:|:...| ...:|.|..|.|::
Human   308 ---KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 369

  Fly   750 LQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSL 814
            |.|:.:...|......|...|:||:..|.|||.::|:||||||||.|:...|..|::|||:|| |
Human   370 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-L 433

  Fly   815 RPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL 879
            ..|.| |....|.::||:|.||||.....||..||||:|||.:||:.:.|..||..|.......|
Human   434 MTGDT-YTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 497

  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF 921
            ::.|.|:.||..||..:|.:|::|||..|.|||:|....:.|
Human   498 LEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	100/258 (39%)
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	7/37 (19%)
		SH2_ABL	169..262	CDD:198189	24/161 (15%)
		PTKc_Abl	281..543	CDD:270645	101/269 (38%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		12/25 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885