Protein Alignment Shark and Jak3

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_036987.2
• Gene: Jak3 / 25326
• RGDID: 2940
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1150
• Identity: 252/1150 - (21%)
• Similarity: 396/1150 - (34%)
• Gaps: 381/1150 - (33%)

  Fly    39 STAAGDFVLSLLC--QGEVC-----HYQVRRHGGEDA--------FFSIDDKVQTKIL------- 81
            |.:.||::...||  ..:.|     ::.:.....||.        .|||:| |.|::|
  Rat    42 SFSFGDYLAEDLCVRAAKACGILPVYHSLFALATEDLSCWFPPSHIFSIED-VDTQVLVYRLRFY 105

  Fly    82 ----HGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELLKC 142
                .||:|...:      ||...||..::.            .::|....:::.|.:|...|..
  Rat   106 FPGWFGLETCHRF------GLHKDLTSAILD------------VHVLEHLFAQHRSDLVSGRLPV 152

  Fly   143 GYRNFDAKNQDGQTALHLAALHSDE-----DILKHL---------LNAKVQVNSSDSF------- 186
            |....|.........|.||.:...:     ::||.:         |...:|   ..||
  Rat   153 GLSLKDQGEFLSLAVLDLAQMARKQAQRPGELLKSVSYKACLPPSLRDLIQ---GQSFVTRRRIR 214

  Fly   187 -----------GCQPLHYAARSK---------PA----SFIRTLISAQ-----ANVQGRNIDNGY 222
                       .||...||..:|         ||    ||:..|..||     ..|.|   |||.
  Rat   215 RTVVQALRRVVACQADRYALMAKYILDLERLHPAATTESFLVGLPGAQEEPGCLRVTG---DNGI 276

  Fly   223 ---------------------VPLHEAAKHG-----NLEAVQ----ELLLAEAPPLPRTSS---- 253
                                 |.:.:|.:.|     .|..:.    .:|.||.|.||...|
  Rat   277 AWSSKDQELFQTFCDFPEIVDVSIKQAPRVGPAGEHRLVTITRMDGHILEAEFPGLPEALSFVAL 341

  Fly   254 GEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRD-QWYHGTLTREEAVAILKK----HAKELLAKQ 313
            .:..|.|..::     ..|......||.....: :..||.:|.:.|:..||.    ....:|.:.
  Rat   342 VDGYFRLICDS-----RHFFCKEVAPPRLLEEEAELCHGPITLDFAIHKLKAAGSLPGSYILRRS 401

  Fly   314 PE----------------VDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKV 362
            |:                .|..|| |:|...|.|.|.:.|:    |:.::.:......:.:|
  Rat   402 PQDYDSFLLTACVQTPLGPDYKGC-LIRQDPSGAFSLVGLS----QLHRSLQELLTACWHSG--- 458

  Fly   363 QSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPE--------------VP- 412
                   |.:|                    |..::|.....|:||.:              .|
  Rat   459 -------LQVD--------------------GTALNLTSCCVPRPKEKSNLIVVRRGRNPTPAPG 496

  Fly   413 -----------SFATIPRSNM------------------KPKAASPATPPTPV---SPHSHHQ-- 443
                       ||.|||..::                  :.:.....|..|.|   ...|.||
  Rat   497 HSPSCCALTKLSFHTIPADSLEWHENLGHGSFTKIFHGHRREVVDGETHDTEVLLKVMDSRHQNC 561

  Fly   444 ---------------HPHVPAL----------------------TITKKKQKENSSSMFNTLRLT 471
                           :||:..|                      |..:|:.....:|.    :|.
  Rat   562 MESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDTYLRKRGHLVPASW----KLQ 622

  Fly   472 SPKKALFDMNSLRK------NKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFST------ 524
            ..|:..:.:|.|..      |.|..|...:...|.|:....:......:|.:.||...|
  Rat   623 VTKQLAYALNYLEDKGLPHGNVSARKVLLAREGVDGNPPFIKLSDPGVSPTVLSLEMLTDRIPWV 687

  Fly   525 ------EFSTFNADGVTGSGAAAAGEVYN-VPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIER 582
                  |..|.|.:.......|...||:: .|.:.|.:|         ...:::::
  Rat   688 APECLQEAGTLNLEADKWGFGATTWEVFSGAPMHITSLE---------PAKKLKFY--------- 734

  Fly   583 ERAGQ-----WIGNGYQPTMDVLSLLDQQI-----KAPAV-ARLNSLGPNASTESEMASYLHRKC 636
            |..||     |        .::..|:.|.:     :.|:. |.|..|....:::.|:.|
  Rat   735 EDRGQLPALKW--------TELEGLIAQCMAYDPGRRPSFRAILRDLNGLITSDYELLS------ 785

  Fly   637 SGTPSTPS-------ATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLE 694
            ..||..|:       ..::.|.:.....|...|.....:|.|.||||.   |.|....|:.:...
  Rat   786 DPTPGIPNPRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVE---LCRYDPLGDNTGPL 847

  Fly   695 VAIKMLSDEHS---NKQEFLREASVMMRLEHKCIVRLIGIAKG---EMLMMVQELAPLGSMLQYI 753
            ||:|.|  :||   .:::|.||..::..|....||:..|::.|   :.|.:|.|..|.|.:..::
  Rat   848 VAVKQL--QHSGPEQQRDFQREIQILKALHCDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 910

  Fly   754 LDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGS 818
            ..|...: .|..|.::|.||..||.||.::..|||||||||||:.:....||:|||:::.|..|.
  Rat   911 QRHRARL-HNDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGK 974

  Fly   819 TEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSL---GAPPYGEISNV------ 874
            ..|...:.|:.||.||||||.:..|||..||||||||.::|:|:.   ...|..|...:
  Rat   975 DYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYSDKSCSPSTEFLRMMGPERE 1039

  Fly   875 -----DAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
                 ..::|:..|.|||.|:.||..:..:||.||...|:|||.|
  Rat  1040 GSPLCHLLELLAEGRRLPPPSTCPTEVQELMQLCWSPNPQDRPAF 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	18/77 (23%)
		ANKYR	<94..317	CDD:440430	60/327 (18%)
		ANK repeat	124..151	CDD:293786	6/26 (23%)
		ANK repeat	153..184	CDD:293786	7/44 (16%)
		ANK repeat	186..217	CDD:293786	15/66 (23%)
		ANK repeat	220..245	CDD:293786	8/54 (15%)
		SH2_Cterm_shark_like	287..395	CDD:198211	21/127 (17%)
		PTKc_Syk_like	666..926	CDD:270650	97/268 (36%)
Jak3	NP_036987.2	cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..223		37/202 (18%)
		FERM_F1	41..114	CDD:465733	17/72 (24%)
		FERM_B-lobe	126..245	CDD:481193	20/133 (15%)
		FERM_C_JAK3	250..359	CDD:275413	24/116 (21%)
		SH2	359..455	CDD:472789	20/100 (20%)
		Protein Kinases, catalytic domain	517..774	CDD:473864	43/286 (15%)
		Protein Kinases, catalytic domain	813..1095	CDD:473864	99/277 (36%)