DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and FGR

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_005239.1 Gene:FGR / 2268 HGNCID:3697 Length:529 Species:Homo sapiens


Alignment Length:574 Identity:157/574 - (27%)
Similarity:248/574 - (43%) Gaps:132/574 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   402 PVPPQPKPEVPSFATIPR-SNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMF 465
            |.|.:.:| ..|||.||. ||...:|.:|.               .:.:.||      ...|.:.
Human    36 PDPTKARP-ASSFAHIPNYSNFSSQAINPG---------------FLDSGTI------RGVSGIG 78

  Fly   466 NTLRLTSPKKALFDMNSLRKNK---SKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFS 527
            .||.:     ||:|..:..::.   :||::..       .|..||.:...|    :|||      
Human    79 VTLFI-----ALYDYEARTEDDLTFTKGEKFH-------ILNNTEGDWWEA----RSLS------ 121

  Fly   528 TFNADGVTGSGAAAAGEVYNVPRNN-TPIEIDLPPIAQKTEAEVEYFTKSDVAIERERA------ 585
                .|.||.          :|.|. .|::        ..:||..||.|    |.|:.|      
Human   122 ----SGKTGC----------IPSNYVAPVD--------SIQAEEWYFGK----IGRKDAERQLLS 160

  Fly   586 -----GQWIGNGYQPTMDVLSL----LDQ----QIKAPAVARLNSLGPNASTESE---------- 627
                 |.::....:.|....||    .||    .:|...:.:|:..|...:|..:          
Human   161 PGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225

  Fly   628 -------MASYLHRKCS-GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRK 684
                   :.:.|...|: ..|.|     :..||..:.|....:.|:|.:|.|.||.|   ||...
Human   226 YMEVNDGLCNLLIAPCTIMKPQT-----LGLAKDAWEISRSSITLERRLGTGCFGDV---WLGTW 282

  Fly   685 SGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSM 749
            :|:     .:||:|.|.....:.:.||.||.||..|.|..:|:|..:...|.:.:|.|....||:
Human   283 NGS-----TKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSL 342

  Fly   750 LQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSL 814
            |.::.:...:.....:|...|:|:|.||.|:|..:::||||.|.|||:..|...||:|||::|.:
Human   343 LDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407

  Fly   815 RPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL 879
            :  ..||...||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||..::..:.::.
Human   408 K--DDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470

  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            |:.|..:|.|..|||.:|..|:..|:..|::||||.||..|.     :.:|.||
Human   471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQ 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 93/264 (35%)
FGRNP_005239.1 SH3 80..137 CDD:473055 20/92 (22%)
SH2_Src_Fgr 140..240 CDD:198230 19/103 (18%)
Protein Kinases, catalytic domain 267..514 CDD:473864 93/256 (36%)
Blue background indicates that the domain is not in the aligned region.

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