DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and FGFR4

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens


Alignment Length:811 Identity:202/811 - (24%)
Similarity:301/811 - (37%) Gaps:210/811 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 EAAKHGNLEAV---------QELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPAN 282
            ||::...||..         |||.:|...|: |...|.     |:..|....|    ..:|.||.
Human    23 EASEEVELEPCLAPSLEQQEQELTVALGQPV-RLCCGR-----AERGGHWYKE----GSRLAPAG 77

  Fly   283 TTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKN 347
            ..|     |...|.|..:.|.:.|...|          |.         |.|.::      |::|
Human    78 RVR-----GWRGRLEIASFLPEDAGRYL----------CL---------ARGSMI------VLQN 112

  Fly   348 FRISQADLYQNGNKVQSGGS------KFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQ 406
            ..:...|...:.|..:...|      :..|....|||...:.:.........|..|..:.|....
Human   113 LTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGN 177

  Fly   407 PKPEVPSFATIPRSNMKPKAASPATPPTPVSPHS---------HHQH------PHVPALTITKKK 456
            |.|.:        ..:|...|.          |.         .|||      ..||:...|...
Human   178 PTPTI--------RWLKDGQAF----------HGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224

  Fly   457 QKENS--SSMFNTL---RLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPM 516
            ..||:  |..:|.|   ...||.:.:... .|..|.:....||.|     .|.....:.|.....
Human   225 LVENAVGSIRYNYLLDVLERSPHRPILQA-GLPANTTAVVGSDVE-----LLCKVYSDAQPHIQW 283

  Fly   517 LKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIE 581
            ||.:..:.  |:|.|||..........::                  ..:|.||.|...    :.
Human   284 LKHIVING--SSFGADGFPYVQVLKTADI------------------NSSEVEVLYLRN----VS 324

  Fly   582 RERAGQW-------IGNGYQ-----------PT----------------------MDVLSLLD-- 604
            .|.||::       ||..||           ||                      :.||.||.  
Human   325 AEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGL 389

  Fly   605 -----------------QQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAK 652
                             |::....:||..||...:|.:|  :|.|.|....:.|.| |.......
Human   390 YRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKS--SSSLVRGVRLSSSGP-ALLAGLVS 451

  Fly   653 LRFFIEP------EKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQ--E 709
            |...::|      ::|||.:.:|.|.||.|..........|..:....||:|||.|..|:|.  :
Human   452 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD 516

  Fly   710 FLREASVMMRL-EHKCIVRLIGIAKGE-MLMMVQELAPLGSMLQYILDH---GHEITANAE---- 765
            .:.|..||..: .||.|:.|:|:...| .|.::.|.|..|::.:::...   |.:::.:..    
Human   517 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSE 581

  Fly   766 -------LKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQF 823
                   |...|.|:|.||.||||:..:||||||||:|:|..:..||:|||::|.:. ....|:.
Human   582 GPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKK 645

  Fly   824 TQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQ 888
            |..||.|::|.|||:....:::|.|||||||:.:||:|:||..||..|...:...|:..|.|:.:
Human   646 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 710

  Fly   889 PNLCPAYIYAVMQSCWKERPKDRPTFVYLTE 919
            |..||..:|.:|:.||...|..||||..|.|
Human   711 PPHCPPELYGLMRECWHAAPSQRPTFKQLVE 741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430 24/98 (24%)
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786 8/26 (31%)
SH2_Cterm_shark_like 287..395 CDD:198211 18/113 (16%)
PTKc_Syk_like 666..926 CDD:270650 96/272 (35%)
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046 21/101 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148 4/28 (14%)
IgI_2_FGFR 147..241 CDD:409443 22/111 (20%)
Ig strand A 147..150 CDD:409443 2/2 (100%)
Ig strand A' 158..163 CDD:409443 0/4 (0%)
Ig strand B 167..175 CDD:409443 2/7 (29%)
Ig strand C 181..186 CDD:409443 0/12 (0%)
Ig strand C' 189..191 CDD:409443 0/1 (0%)
Ig strand D 200..203 CDD:409443 0/2 (0%)
Ig strand E 207..212 CDD:409443 0/4 (0%)
Ig strand F 221..228 CDD:409443 1/6 (17%)
Ig strand G 231..241 CDD:409443 3/9 (33%)
Ig 249..351 CDD:472250 25/131 (19%)
Ig strand B 267..271 CDD:409444 1/8 (13%)
Ig strand C 280..284 CDD:409444 0/3 (0%)
Ig strand E 316..320 CDD:409444 2/3 (67%)
Ig strand F 330..335 CDD:409444 0/4 (0%)
Ig strand G 343..346 CDD:409444 2/2 (100%)
Protein Kinases, catalytic domain 454..767 CDD:473864 100/289 (35%)
Blue background indicates that the domain is not in the aligned region.

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