Protein Alignment Shark and Zap70

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_001276695.1
• Gene: Zap70 / 22637
• MGIID: 99613
• Length: 642
• Species: Mus musculus
• Alignment Length: 928
• Identity: 231/928 - (24%)
• Similarity: 342/928 - (36%)
• Gaps: 362/928 - (39%)

  Fly     6 DP---MKWYHGNLSREAADELLK-QGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH--- 63
            ||   :.:::|::||..|:|.|| .|..||.||:|:...:.|.:||||:......|:.:.|.
Mouse    27 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 91

  Fly    64 -----GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNL 123
                 ||             |...|...|..:|.|..:|||..|..|..|  ||......|
Mouse    92 TYAIAGG-------------KAHCGPAELCQFYSQDPDGLPCNLRKPCNR--PPGLEPQPG---- 137

  Fly   124 LHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGC 188
                        ||:.|:      ||
Mouse   138 ------------VFDCLR------DA--------------------------------------- 145

  Fly   189 QPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSS 253
                         .:|..:.....::|                   :|:::.::::||
Mouse   146 -------------MVRDYVRQTWKLEG-------------------DALEQAIISQAP------- 171

  Fly   254 GEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDT 318
                 .:.|....||.|      ::|        |||.:||||||       .::|.:.|   .|
Mouse   172 -----QVEKLIATTAHE------RMP--------WYHSSLTREEA-------ERKLYSGQ---QT 207

  Fly   319 SGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEH 383
            .|.||:|..:....  ..|:|:..:.|.::.|||.   :.|......|:||     ...|..||:
Mouse   208 DGKFLLRPRKEQGT--YALSLVYGKTVYHYLISQD---KAGKYCIPEGTKF-----DTLWQLVEY 262

  Fly   384 LIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVP 448
            |...    :.||...||         ||     .|.|:.....|:|..|          .||
Mouse   263 LKLK----ADGLIYRLK---------EV-----CPNSSASAAVAAPTLP----------AHP--- 296

  Fly   449 ALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAA 513
                          |.|     |.|::.:
Mouse   297 --------------STF-----TQPQRRV------------------------------------ 306

  Fly   514 APMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDV 578
                         .|.|:||.|...|..|... :.||   |:.:|
Mouse   307 -------------DTLNSDGYTPEPARLASST-DKPR---PMPMD-------------------- 334

  Fly   579 AIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTP 643
                                                                      :....:|
Mouse   335 ----------------------------------------------------------TSVYESP 341

  Fly   644 SATEVEAAKLRFFIEPEK-LVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSD--EH 704
            .:...|....:.|::.|. ||.|.|:|.|.||||..| :.:||      .:::||||:|..  |.
Mouse   342 YSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRK------KQIDVAIKVLKQGTEK 400

  Fly   705 SNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITAN--AELK 767
            ::|.|.:|||.:|.:|::..||||||:.:.|.||:|.|:|..|.:.:::|....||..:  |||
Mouse   401 ADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKEEIPVSNVAEL- 464

  Fly   768 VWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIR 832
              ..|:|.||.|||.::||||||||||:||..||.|||||||:|::|....:.|.....|:||::
Mouse   465 --LHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 527

  Fly   833 WYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIY 897
            |||||..|...||..|||||:|||:||.||.|..||.::...:.:..:..|:|:..|..||..:|
Mouse   528 WYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMY 592

  Fly   898 AVMQSCWKERPKDRPTFV 915
            |:|..||..:.:|||.|:
Mouse   593 ALMSDCWIYKWEDRPDFL 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	25/91 (27%)
		ANKYR	<94..317	CDD:440430	35/222 (16%)
		ANK repeat	124..151	CDD:293786	5/26 (19%)
		ANK repeat	153..184	CDD:293786	0/30 (0%)
		ANK repeat	186..217	CDD:293786	2/30 (7%)
		ANK repeat	220..245	CDD:293786	1/24 (4%)
		SH2_Cterm_shark_like	287..395	CDD:198211	30/107 (28%)
		PTKc_Syk_like	666..926	CDD:270650	113/255 (44%)
Zap70	NP_001276695.1	SH2_N-SH2_Zap70_Syk_like	32..135	CDD:198191	35/117 (30%)
		SH2	176..280	CDD:472789	40/155 (26%)
		PTKc_Zap-70	356..624	CDD:270686	117/264 (44%)