Protein Alignment Shark and FGFR2

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_075259.4
• Gene: FGFR2 / 2263
• HGNCID: 3689
• Length: 822
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 176/739 - (23%)
• Similarity: 284/739 - (38%)
• Gaps: 178/739 - (24%)

  Fly   320 GCFLVRYSESPAASGL---VLTLLCDQVVKNFRISQADLYQNGNKVQ--SGGSKFLYIDD----G 375
            |.:|.....:|..|||   ..:...|.....|.::..|...:|:...  .|...|:..:.    .
Human    89 GEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

  Fly   376 PYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEV------PSFATIPR------SNMKPKAAS 428
            |||.:.|.:............|..:.|....|.|.:      ..|....|      .|.......
Human   154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

  Fly   429 PATPPTPVS-------------PHSHH-----QHPHVPALTITKKKQKENSSSMFNTLRLTSPKK 475
            .:..|:...             .|::|     :.||.|   |.:.....|:|::...
Human   219 ESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRP---ILQAGLPANASTVVGG-------- 272

  Fly   476 ALFDMNSLRKNKSKGKRSDSESSV--------SGSLAGTEQELQAAAPMLKSLSFSTEFSTFNAD 532
               |:..:.|     ..||::..:        :||..|.:     ..|.||.|..|
Human   273 ---DVEFVCK-----VYSDAQPHIQWIKHVEKNGSKYGPD-----GLPYLKVLKHS--------- 315

  Fly   533 GVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEV-EYFTKSDVAIERERAGQWI------- 589
            |:..|.|.... ::||                 |||:. ||..|....|.:.....|:
Human   316 GINSSNAEVLA-LFNV-----------------TEADAGEYICKVSNYIGQANQSAWLTVLPKQQ 362

  Fly   590 --GNGYQPTMD-------------------VLSLLDQQIK----------APAVARLNSLGP--- 620
              |...:.|..                   |::::..::|          .|||.:|....|
Human   363 APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRR 427

  Fly   621 ----NASTESEMAS-----YLHRKCSGTPSTPSATEVEAAKL----RFFIEPEKLVLDREIGHGE 672
                :|.:.|.|.|     .:..:.|.|..||....|...:|    ::....:||.|.:.:|.|.
Human   428 QVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGC 492

  Fly   673 FGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNK--QEFLREASVMMRL-EHKCIVRLIGIAKG 734
            ||.|.....:.......:..:.||:|||.|:.:.|  .:.:.|..:|..: :||.|:.|:|....
Human   493 FGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 557

  Fly   735 E-MLMMVQELAPLGSMLQYI-------LDHGHEITANAE-------LKVWASQIACGMHYLESQH 784
            : .|.::.|.|..|::.:|:       :::.::|....|       |.....|:|.||.||.||.
Human   558 DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK 622

  Fly   785 FVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASD 849
            .:||||||||:|:|..:..||:|||::|.:. ....|:.|..||.|::|.|||:....:::|.||
Human   623 CIHRDLAARNVLVTENNVMKIADFGLARDIN-NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 686

  Fly   850 VWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            ||||||.:||:|:||..||..|...:..||:..|.|:.:|..|...:|.:|:.||...|..||||
Human   687 VWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 751

  Fly   915 VYLTEFFAR------DPDYQNLPE 932
            ..|.|...|      :.:|.:|.:
Human   752 KQLVEDLDRILTLTTNEEYLDLSQ 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211	16/83 (19%)
		PTKc_Syk_like	666..926	CDD:270650	95/283 (34%)
FGFR2	NP_075259.4	IgI_1_FGFR	31..124	CDD:409362	8/34 (24%)
		Ig strand A	31..34	CDD:409362
		Ig strand A'	47..53	CDD:409362
		Ig strand B	56..66	CDD:409362
		Ig strand C	69..74	CDD:409362
		Ig strand C'	77..79	CDD:409362
		Ig strand D	84..88	CDD:409362
		Ig strand E	91..96	CDD:409362	1/4 (25%)
		Ig strand F	102..111	CDD:409362	3/8 (38%)
		Ig strand G	114..124	CDD:409362	2/9 (22%)
		IgI_2_FGFR	154..248	CDD:409443	14/93 (15%)
		Ig strand A	154..157	CDD:409443	2/2 (100%)
		Ig strand A'	165..170	CDD:409443	0/4 (0%)
		Ig strand B	174..182	CDD:409443	2/7 (29%)
		Ig strand C	188..193	CDD:409443	0/4 (0%)
		Ig strand C'	196..198	CDD:409443	0/1 (0%)
		Ig strand D	207..210	CDD:409443	0/2 (0%)
		Ig strand E	214..219	CDD:409443	0/4 (0%)
		Ig strand F	228..235	CDD:409443	0/6 (0%)
		Ig strand G	238..248	CDD:409443	2/9 (22%)
		Ig	256..358	CDD:472250	29/152 (19%)
		Ig strand B	274..278	CDD:409353	0/3 (0%)
		Ig strand C	287..291	CDD:409353	0/3 (0%)
		Ig strand E	323..327	CDD:409353	0/4 (0%)
		Ig strand F	337..342	CDD:409353	2/4 (50%)
		Ig strand G	350..353	CDD:409353	0/2 (0%)
		PTKc_FGFR2	457..769	CDD:270679	102/312 (33%)