DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and FGFR1

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001167538.1 Gene:FGFR1 / 2260 HGNCID:3688 Length:853 Species:Homo sapiens


Alignment Length:742 Identity:184/742 - (24%)
Similarity:300/742 - (40%) Gaps:198/742 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   345 VKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVP----- 404
            |::|.:...||.|...:::.......::.||     |:...::..|.: |..|.::..||     
Human    73 VESFLVHPGDLLQLRCRLRDDVQSINWLRDG-----VQLAESNRTRIT-GEEVEVQDSVPADSGL 131

  Fly   405 -----PQPKPEVPSFATIPRSNMKPKA--------------ASPATPPTPV-----SPHSHHQHP 445
                 ..|.....::.::..|:..|.:              .:..|.|.||     ||....:..
Human   132 YACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKL 196

  Fly   446 HVPALTITKKKQKENSSSMFNTLR-LTSPKKALFD----------------MNSLRKNKSKGKRS 493
            |......|.|.:..:|.:...||| |.:.|:...|                |:|:..: .||..:
Human   197 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPS-DKGNYT 260

  Fly   494 DSESSVSGSLAGTEQ-----------ELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYN 547
            ....:..||:..|.|           .|||..|..|:::.             ||......:||:
Human   261 CIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL-------------GSNVEFMCKVYS 312

  Fly   548 VPR-----------NNTPIEIDLPPIAQ--------KTEAEVEYFTKSDVAIERERAGQW---IG 590
            .|:           |.:.|..|..|..|        .|:.|:|.....:|:.  |.||::   .|
Human   313 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSF--EDAGEYTCLAG 375

  Fly   591 NG-----YQPTMDVLSLLDQQIKAPAVA----------------------------RLNSLGPNA 622
            |.     :...:.||..|:::   |||.                            ::.|....:
Human   376 NSIGLSHHSAWLTVLEALEER---PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKS 437

  Fly   623 STESEMASY-------LHRK------------------------CSGTPSTPSATEVEAAK-LRF 655
            ...|:||.:       |.|:                        .||||.....:|.|..: .|:
Human   438 DFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRW 502

  Fly   656 FIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEE--SRL-EVAIKMLSDEHSNK--QEFLREAS 715
            .:..::|||.:.:|.|.||.|   .|....|..::  :|: :||:|||..:.:.|  .:.:.|..
Human   503 ELPRDRLVLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME 564

  Fly   716 VMMRL-EHKCIVRLIG--------------IAKGEMLMMVQELAPLGSMLQYILDHGH---EITA 762
            :|..: :||.|:.|:|              .:||.:...:|...|.|  |:|..:..|   |..:
Human   565 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG--LEYCYNPSHNPEEQLS 627

  Fly   763 NAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGG 827
            :.:|...|.|:|.||.||.|:..:||||||||:|:|..:..||:|||::|.:. ....|:.|..|
Human   628 SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH-HIDYYKKTTNG 691

  Fly   828 RWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLC 892
            |.|::|.|||:....|::|.||||||||.:||:|:||..||..:...:..||:..|.|:.:|:.|
Human   692 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC 756

  Fly   893 PAYIYAVMQSCWKERPKDRPTFVYLTE 919
            ...:|.:|:.||...|..||||..|.|
Human   757 TNELYMMMRDCWHAVPSQRPTFKQLVE 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211 9/49 (18%)
PTKc_Syk_like 666..926 CDD:270650 98/277 (35%)
FGFR1NP_001167538.1 IgI_1_FGFR 58..151 CDD:409362 14/83 (17%)
Ig strand A 58..61 CDD:409362
Ig strand A' 73..79 CDD:409362 2/5 (40%)
Ig strand B 82..92 CDD:409362 3/9 (33%)
Ig strand C 96..101 CDD:409362 0/4 (0%)
Ig strand C' 104..106 CDD:409362 1/1 (100%)
Ig strand D 111..115 CDD:409362 1/3 (33%)
Ig strand E 118..123 CDD:409362 1/4 (25%)
Ig strand F 129..138 CDD:409362 0/8 (0%)
Ig strand G 141..151 CDD:409362 0/9 (0%)
IgI_2_FGFR 184..278 CDD:409443 20/94 (21%)
Ig strand A 184..187 CDD:409443 0/2 (0%)
Ig strand A' 195..200 CDD:409443 1/4 (25%)
Ig strand B 204..212 CDD:409443 2/7 (29%)
Ig strand C 218..223 CDD:409443 3/4 (75%)
Ig strand C' 226..228 CDD:409443 1/1 (100%)
Ig strand D 237..240 CDD:409443 0/2 (0%)
Ig strand E 244..249 CDD:409443 0/4 (0%)
Ig strand F 258..265 CDD:409443 0/6 (0%)
Ig strand G 268..278 CDD:409443 4/9 (44%)
Ig 286..390 CDD:472250 24/118 (20%)
Ig strand B 304..308 CDD:409353 0/3 (0%)
Ig strand C 317..321 CDD:409353 0/3 (0%)
Ig strand E 355..359 CDD:409353 1/3 (33%)
Ig strand F 369..374 CDD:409353 0/4 (0%)
Ig strand G 382..385 CDD:409353 0/2 (0%)
PTKc_FGFR1 495..796 CDD:270678 103/295 (35%)
Blue background indicates that the domain is not in the aligned region.

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