Protein Alignment Shark and Syk

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_035648.2
• Gene: Syk / 20963
• MGIID: 99515
• Length: 629
• Species: Mus musculus
• Alignment Length: 934
• Identity: 224/934 - (23%)
• Similarity: 334/934 - (35%)
• Gaps: 359/934 - (38%)

  Fly     8 MKWYHGNLSREAADELLKQ-GYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH-------G 64
            :.::.||::||.|::.|.| |..||.:|:|:|....|.|.||:....:..||.:.|.       .
Mouse    12 LTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAIS 76

  Fly    65 GEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATS 129
            |..|..|..|            |..|:.|..:||...|..|..|  ||
Mouse    77 GGRAHASPAD------------LCHYHSQEPDGLICLLKKPFNR--PP----------------- 110

  Fly   130 KNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYA 194
                                                                     |.||....
Mouse   111 ---------------------------------------------------------GVQPKTGP 118

  Fly   195 ARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFD 259
            ......:.||..:....|:||                   :|:::.::::.|            .
Mouse   119 FEDLKENLIREYVKQTWNLQG-------------------QALEQAIISQKP------------Q 152

  Fly   260 LAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLV 324
            |.|....||.|      |:|        |:||.::|:|:...:...:|          |:|.||:
Mouse   153 LEKLIATTAHE------KMP--------WFHGNISRDESEQTVLIGSK----------TNGKFLI 193

  Fly   325 RYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFM 389
            |..::  :....|.||.:..|.::||   |..:.|......|.||     ...|..|||
Mouse   194 RARDN--SGSYALCLLHEGKVLHYRI---DRDKTGKLSIPEGKKF-----DTLWQLVEH------ 242

  Fly   390 RFSYGLPVSLKYPVPPQPKPE-VPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTIT 453
             :||              ||: :....|:|...:..:...|.:|         :.||
Mouse   243 -YSY--------------KPDGLLRVLTVPCQKIGAQMGHPGSP---------NAHP-------- 275

  Fly   454 KKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLK 518
                                                         |:.|..|       ....:|
Mouse   276 ---------------------------------------------VTWSPGG-------IISRIK 288

  Fly   519 SLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERE 583
            |.||..                        |.:..|    .||...:.|:.|.:
Mouse   289 SYSFPK------------------------PGHKKP----APPQGSRPESTVSF----------- 314

  Fly   584 RAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEV 648
                   |.|:||.                  ...||:...:.|             :.|..|||
Mouse   315 -------NPYEPTG------------------GPWGPDRGLQRE-------------ALPMDTEV 341

  Fly   649 ------EAAKLRFFIEPEKLVLDR--------EIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKM 699
                  :..::|    |:::.|||        |:|.|.||:|..|:...|...     ..||:|:
Mouse   342 YESPYADPEEIR----PKEVYLDRSLLTLEDNELGSGNFGTVKKGYYQMKKVV-----KTVAVKI 397

  Fly   700 LSDEHSN---KQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEIT 761
            |.:|.::   |.|.|.||:||.:|::..|||:|||.:.|..|:|.|:|.||.:.:|:..:.|...
Mouse   398 LKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKD 462

  Fly   762 AN-AELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQ 825
            .| .||   ..|::.||.|||..:||||||||||:||..:|.|||||||:|::||.....|:...
Mouse   463 KNIIEL---VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 524

  Fly   826 GGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPN 890
            .|:||::|||||..|...||..||||||||.:||.||.|..||..:...:...:::.|||:..|.
Mouse   525 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA 589

  Fly   891 LCPAYIYAVMQSCWKERPKDRPTF 914
            .||..:|.:|..||....::||.|
Mouse   590 GCPREMYDLMNLCWTYDVENRPGF 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	25/90 (28%)
		ANKYR	<94..317	CDD:440430	30/222 (14%)
		ANK repeat	124..151	CDD:293786	0/26 (0%)
		ANK repeat	153..184	CDD:293786	0/30 (0%)
		ANK repeat	186..217	CDD:293786	8/30 (27%)
		ANK repeat	220..245	CDD:293786	1/24 (4%)
		SH2_Cterm_shark_like	287..395	CDD:198211	28/107 (26%)
		PTKc_Syk_like	666..926	CDD:270650	109/261 (42%)
Syk	NP_035648.2	SH2_N-SH2_Zap70_Syk_like	12..115	CDD:198191	36/190 (19%)
		Interdomain A	107..166		19/171 (11%)
		SH2_C-SH2_Syk_like	163..261	CDD:198264	35/152 (23%)
		Interdomain B	259..364		33/254 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..328		12/98 (12%)
		PTKc_Syk	370..625	CDD:133247	108/252 (43%)