DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Jak3

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_034719.2 Gene:Jak3 / 16453 MGIID:99928 Length:1100 Species:Mus musculus


Alignment Length:602 Identity:110/602 - (18%)
Similarity:191/602 - (31%) Gaps:194/602 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   849 DEEPIKLFETCVDLRELQ--LNVTLG--FEGLEIRMPGGENVRKA--IIRTIARLQDRLLEVSED 907
            |.:.::.|..|:|.|.|.  |.|..|  |:|....:.|.|.....  :::.|..   .||.||.:
Mouse     3 DLQSLQAFINCLDQRSLPRILQVCSGVYFQGSVYEISGSEVCLSTGDLVKIIGL---ELLSVSCE 64

  Fly   908 DTQTLKAIVTLYEKVLLRKHPNGSYEMQLK------------------------TFNSTKRF--- 945
            |..|..:.|       |..|..|::.:..:                        ||.||:..   
Mouse    65 DVNTGDSFV-------LPIHYTGNFRLVAEDLPYNTVEELVGLCPVGVDACGSFTFRSTQELIVD 122

  Fly   946 -------------------QTYQLTRCKRDVRAVVVTRVIIQ-------QDCRDE---------- 974
                               ...:|.||:.....:....:::.       .:|.||          
Mouse   123 NFTLAPDEHLSLLSVEVSEDGERLARCQVLGHNMAYAELLLPLSLKGEFYECEDERGYFLQEIMS 187

  Fly   975 ---MSLPLFSATHLEVMKKLLELS---------------VSYYSTVRIEAQ---AKLHDMLYLFP 1018
               :|...|..|:.:....||..|               |.:.||:.::.|   .:..|::::.|
Mouse   188 SARLSCRRFCNTNTKSSGGLLMFSPVYEISAIMHLRKNIVKFPSTLEVDVQDVTDQFQDLVFITP 252

  Fly  1019 YAYPLLTDRIVECLQ-----LDANTNHERFKGILCLLFIKRRGRLISQNNWEYLARVWPALLRSK 1078
            .:.|.:..:..|...     |:|...::.|.   |              :|      :..|.:.|
Mouse   253 LSLPEVVSQPKESFPTMAEILEAPEGNQYFS---C--------------SW------FGGLQKGK 294

  Fly  1079 LSVKPSIVKLVDGLKKMIDGQSPT-------YLLEVDIGEKVVERALALRTRVDELDLAPGQAAR 1136
                 |::......|.||...:|.       :::..|.|.::..||....: |.||.||..|:..
Mouse   295 -----SLILHECHQKTMILASTPKGKKGKQYFMISDDYGGRMRRRAREFGS-VYELYLASSQSPG 353

  Fly  1137 AREN-KRNMELFQQLIADIVQTVETSKLHLRYHYLASVMLINLCHPYAEHPPSVTRLTVHHLIHD 1200
            .:.: .|:.|      ||..:.:....:......|...::..|....||...|:.....|.:..|
Mouse   354 LKVSVSRDYE------ADEDEGMPALGVGENLEVLGMSLMDRLKPGAAEKVESLICKRTHEVDDD 412

  Fly  1201 SVTE----RKLAIQLLL-GIFRQQKRPQKKCVMNPL---------EIVAR--------LAGQDG- 1242
            ...:    .::::.|.: |.|.::....||..:|.|         ::|.|        |.|... 
Mouse   413 DDDDEDDSEEISMPLFMAGHFVEKLSDNKKYRLNDLVSGSLPVDVKVVTRDKDLEKDPLMGLPAL 477

  Fly  1243 ------------GSVPPNPGSNVAPGYRDDNMWLQYDVARVPKSQAEWDEPRYMYTVEGCFGWTQ 1295
                        .|:|.||........|    |||..|. .......|..|..:: ||.....|:
Mouse   478 KLEETFTETTVLTSLPHNPDWCFELPVR----WLQMSVC-FTSDDLPWSRPPELH-VETVTEMTE 536

  Fly  1296 GF-----KMYAPSAEQP 1307
            .|     |:...:.|.|
Mouse   537 KFYYEYHKLIGKTEEPP 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 22/82 (27%)
Jak3NP_034719.2 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..223 40/229 (17%)
FERM_F1 41..114 CDD:465733 13/82 (16%)
FERM_B-lobe 126..245 CDD:481193 16/118 (14%)
FERM_C_JAK3 250..359 CDD:275413 25/137 (18%)
SH2 359..455 CDD:472789 18/101 (18%)
Protein Kinases, catalytic domain 517..774 CDD:473864 9/38 (24%)
Protein Kinases, catalytic domain 813..1095 CDD:473864
Blue background indicates that the domain is not in the aligned region.

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