DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Hck

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_034537.2 Gene:Hck / 15162 MGIID:96052 Length:524 Species:Mus musculus


Alignment Length:577 Identity:151/577 - (26%)
Similarity:259/577 - (44%) Gaps:101/577 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   398 SLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHP-HVPALTITKKKQKENS 461
            |.:.|..|:.:...|....:     |.:.....:..:...|.::.:.| :||..|.:.|....||
Mouse     6 SCEDPGCPRSEGRAPRMGCV-----KSRFLRDGSKASKTEPSANQKGPVYVPDPTSSSKLGPNNS 65

  Fly   462 SSM--------FNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLK 518
            :||        .:|:.:     ||:|..::.:.....::.|.           ...|:.|....|
Mouse    66 NSMPPGFVEGSEDTIVV-----ALYDYEAIHREDLSFQKGDQ-----------MVVLEEAGEWWK 114

  Fly   519 SLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEV-EYFTKSDVAIER 582
            :.|.:|:...:                  :|.|.         :|:....|. |:|.|.....:.
Mouse   115 ARSLATKKEGY------------------IPSNY---------VARVNSLETEEWFFKGISRKDA 152

  Fly   583 ER----AGQWIGN----GYQPTMDVLSL----LDQQ----IKAPAVARLNS----LGPNASTESE 627
            ||    .|..:|:    ..:.|....||    .|.|    :|...:..|:|    :.|.::..|.
Mouse   153 ERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSL 217

  Fly   628 MASYLHRK------CS--GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRK 684
            ....||.|      |.  ..|......:....|..:.|..|.|.:::::|.|:||.|   |:   
Mouse   218 QELVLHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEV---WM--- 276

  Fly   685 SGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSM 749
              |......:||:|.:.....:.:.||.||::|..|:|..:|:|..:...|.:.:|.|....||:
Mouse   277 --ATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQEPIFIVTEFMAKGSL 339

  Fly   750 LQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSL 814
            |.::...........:|..:::||:.||.::|.::::||||.|.|||::|....||:|||::|.:
Mouse   340 LDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARII 404

  Fly   815 RPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL 879
            .  ..||...:|.::||:|.|||:.|.|.|:..|||||||:.:.|:.:.|..||..:||.:.|:.
Mouse   405 E--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRA 467

  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            ::.|.|:|:|:.||..:|.:|..|||.||::||||.|    |.:|: |.:..||..|
Mouse   468 LEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 93/264 (35%)
HckNP_034537.2 SH3 80..135 CDD:473055 12/97 (12%)
SH2_Src_HCK 138..241 CDD:198226 23/102 (23%)
Protein Kinases, catalytic domain 252..522 CDD:473864 97/279 (35%)
Blue background indicates that the domain is not in the aligned region.

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