DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Fyn

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_030100741.1 Gene:Fyn / 14360 MGIID:95602 Length:576 Species:Mus musculus


Alignment Length:564 Identity:151/564 - (26%)
Similarity:234/564 - (41%) Gaps:129/564 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 TPPTPVSPHSHHQHPHVPALTITKKKQKE----------------NSSSMFNTLRLTSPK----- 474
            |.|||         .|.|:..:|......                ||||...|||.....     
Mouse    71 TDPTP---------QHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLF 126

  Fly   475 KALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGA 539
            .||:|..                      |.||.:|.........:..|:|...:.|..:|    
Mouse   127 VALYDYE----------------------ARTEDDLSFHKGEKFQILNSSEGDWWEARSLT---- 165

  Fly   540 AAAGEVYNVPRNN-TPIEIDLPPIAQKTEAEVEYFTK---SDVAIERE-------------RAGQ 587
              .||...:|.|. .|::        ..:||..||.|   .|.  ||:             |..:
Mouse   166 --TGETGYIPSNYVAPVD--------SIQAEEWYFGKLGRKDA--ERQLLSFGNPRGTFLIRESE 218

  Fly   588 WIGNGYQPTMDVLSLLD------QQIKAPAVARLNSLGPNASTES------EMASYLHRKCSGT- 639
            .....|.     ||:.|      ..:|...:.:|::.|...:|.:      ::..:...:.:|. 
Mouse   219 TTKGAYS-----LSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLC 278

  Fly   640 --------PSTPSATEVEA-AKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLE 694
                    ...|..|::.. .|..:.|..|.|.|.:.:|:|:||.|..| |         ....:
Mouse   279 CRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTW---------NGNTK 334

  Fly   695 VAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHE 759
            ||||.|.....:.:.||.||.:|.:|:|..:|:|..:...|.:.:|.|....||:|.::.|....
Mouse   335 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGR 399

  Fly   760 ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFT 824
            ......|...|:|:|.||.|:|..:::||||.:.|||:......||:|||::|.:.  ..||...
Mouse   400 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE--DNEYTAR 462

  Fly   825 QGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQP 889
            ||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||..::|.:.::.|:.|.|:|.|
Mouse   463 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 527

  Fly   890 NLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            ..||..::.:|..|||:.|::||||.||..|.     |.:|.||
Mouse   528 QDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 93/265 (35%)
FynXP_030100741.1 SH3_Fyn_Yrk 124..179 CDD:212939 15/82 (18%)
SH2_Src_Fyn_isoform_a_like 184..284 CDD:198281 18/106 (17%)
PTKc_Fyn 300..573 CDD:270655 101/283 (36%)
Blue background indicates that the domain is not in the aligned region.

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