Protein Alignment Shark and Csk

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_031809.2
• Gene: Csk / 12988
• MGIID: 88537
• Length: 450
• Species: Mus musculus
• Alignment Length: 278
• Identity: 101/278 - (36%)
• Similarity: 153/278 - (55%)
• Gaps: 25/278 - (8%)

  Fly   650 AAKLRFF-----IEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQE 709
            ||:..|:     :..::|.|.:.||.||||.|.         .|:....:||:|.:.:: :..|.
Mouse   178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVM---------LGDYRGNKVAVKCIKND-ATAQA 232

  Fly   710 FLREASVMMRLEHKCIVRLIGIAKGEM--LMMVQELAPLGSMLQYILDHGHEITANAELKVWASQ 772
            ||.|||||.:|.|..:|:|:|:...|.  |.:|.|....||::.|:...|..:.....|..::..
Mouse   233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297

  Fly   773 IACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQG-GRWPIRWYAP 836
            :...|.|||..:||||||||||:|::..:.||:||||:::       |...||. |:.|::|.||
Mouse   298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-------EASSTQDTGKLPVKWTAP 355

  Fly   837 ESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQ 901
            |:.....||..|||||||:.:||::|.|..||..|...|.:..|:.|.::..|:.||..:|.||:
Mouse   356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 420

  Fly   902 SCWKERPKDRPTFVYLTE 919
            :||......||||:.|.|
Mouse   421 NCWHLDAATRPTFLQLRE 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	96/257 (37%)
Csk	NP_031809.2	Interaction with PTPN22. /evidence=ECO:0000269|PubMed:8890164	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190
		PTKc_Csk	188..443	CDD:133213	98/268 (37%)