Protein Alignment Shark and Bmx

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_033889.2
• Gene: Bmx / 12169
• MGIID: 1101778
• Length: 655
• Species: Mus musculus
• Alignment Length: 789
• Identity: 190/789 - (24%)
• Similarity: 309/789 - (39%)
• Gaps: 192/789 - (24%)

  Fly   167 EDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKH 231
            :.||:.||..|.|.....|    |.:|    |...|:.|..|...        ..|..:...::.
Mouse     8 KSILEELLLKKSQQKKKMS----PNNY----KERLFVLTKTSLSY--------YEYDKMKRGSRK 56

  Fly   232 GNLE-----AVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHG 291
            |::|     .|:::.|.|..|:.|    ::||.:..:.|        |.|.......:|.||
Mouse    57 GSIEIKKIRCVEKVNLEEQTPVER----QYPFQIVYKDG--------LLYVYASNEESRCQW--- 106

  Fly   292 TLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVK-----NFRIS 351
                             |.|.|.|:..:...|::|.......|..  |.|.|..|     ....:
Mouse   107 -----------------LKALQKEIRGNPHLLIKYHSGFFVDGKF--LCCQQSCKAAPGCTLWEA 152

  Fly   352 QADLYQNGNKVQSGGSKFLYIDD----GPYWPSVEHLIAHFMRFSYGLPVSLKYP--VPPQPKPE 410
            .|||:             :.|.|    .|.:|  |.|              ||.|  ||......
Mouse   153 YADLH-------------IAISDEKHRAPTFP--ERL--------------LKIPRAVPVLKMDA 188

  Fly   411 VPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKK 475
            ..|.|.:|:.:...|.:..:.|.:.:.        ::|         :|:....:...:|.| ::
Mouse   189 SSSGAILPQYDSYSKKSCGSQPTSNIR--------YIP---------REDCPDWWQVRKLKS-EE 235

  Fly   476 ALFDMNSLRKNKSKGKRSDSESSVS-----GSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVT 535
            .:...|.|.:|.:    |.|.|.:|     .|.:..|:.|.|......::|.|.........|..
Mouse   236 DIACSNQLERNIA----SHSTSKMSWGFPESSSSEEEENLHAYDWFAGNISRSQSEQLLRQKGKE 296

  Fly   536 GSGAAAAGEVYNVPRNNTPIEIDLPPIAQK---------------TEAEVEYFTKSDVAIERERA 585
            |:         .:.||::.:.:....:..|               |.||.:.:...:...:
Mouse   297 GA---------FMVRNSSQMGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFD---- 348

  Fly   586 GQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEA 650
                      ::..|....|...|..:.||                  |....|.:......|..
Mouse   349 ----------SIPKLIHYHQHNSAGMITRL------------------RHPVSTKANKVPVSVAL 385

  Fly   651 AKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREA 714
            ....:.::.|::.|.:|:|:|:||.|..| |         :.:.:||:||:.:...::.||.:||
Mouse   386 GSGIWELKREEITLLKELGNGQFGVVQLGQW---------KGQYDVAVKMIKEGAMSEDEFFQEA 441

  Fly   715 SVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMH 778
            ..||:|.|..:|:..|: :|...:.:|.|....|.:|.|:..||..: .:.:|......:..||.
Mouse   442 QTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGL-ESCQLLEMCYDVCEGMA 505

  Fly   779 YLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGI 843
            :|||..|:||||||||.|:.:....|:|||||:|.:.  ..:|..:.|.::|::|.|||.|:...
Mouse   506 FLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVL--DDQYVSSVGTKFPVKWSAPEVFHYFK 568

  Fly   844 FSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERP 908
            :|..||||:||:.:||:||||..||....|.:.:..|..|.||.:|.|....||.:|.|||.|.|
Mouse   569 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELP 633

  Fly   909 KDRPTFVYL 917
            :.||||..|
Mouse   634 EKRPTFQQL 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430	33/154 (21%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786	6/16 (38%)
		ANK repeat	186..217	CDD:293786	6/30 (20%)
		ANK repeat	220..245	CDD:293786	5/29 (17%)
		SH2_Cterm_shark_like	287..395	CDD:198211	22/116 (19%)
		PTKc_Syk_like	666..926	CDD:270650	96/254 (38%)
Bmx	NP_033889.2	PH_Btk	25..151	CDD:269944	34/175 (19%)
		SH2_Tec_Bmx	269..374	CDD:198262	18/145 (12%)
		Protein Kinases, catalytic domain	392..647	CDD:473864	98/263 (37%)