DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and fgfr3

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_012812743.1 Gene:fgfr3 / 100196923 XenbaseID:XB-GENE-479255 Length:829 Species:Xenopus tropicalis


Alignment Length:811 Identity:192/811 - (23%)
Similarity:318/811 - (39%) Gaps:222/811 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 APPLPRTSSGEF---------------PFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLT 294
            |..||.|..||.               |||   |...|..|...|:.....|:|| .:|:     
 Frog    39 AARLPVTLPGEDRASRKASDYITVEQPPFD---ELMFTIGETIELSCAAEDASTT-TKWF----- 94

  Fly   295 REEAVAIL---KKHAKELLAKQPEV--DTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQAD 354
             ::.:||:   :.:.::.|.|...:  |.||.:..|...|            .::::||.|...|
 Frog    95 -KDGIAIVPNNRTNTRQGLLKIINISYDDSGIYSCRLWHS------------TEILRNFTIRVTD 146

  Fly   355 LYQNGNKVQSGGSKFLYIDD-------GPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVP 412
            |..:|:....        ||       .|.|                          .||:....
 Frog   147 LPSSGDDEDD--------DDEETEDREPPRW--------------------------TQPEKMDK 177

  Fly   413 SFATIPRSN----MKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSP 473
            ....:|.:|    ..|.|.:|                 .|.:...|..::.........::|...
 Frog   178 KLTAVPAANTIRFRCPAAGNP-----------------TPTIHWLKNGKEFRGEHRIGGIKLRHQ 225

  Fly   474 KKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQ----ELQAAAPMLKSLSFSTEFSTFNAD-- 532
            :.:|. |.|:..: .||..:....:..||:..|.|    |..:..|:|::...:.:.....:|  
 Frog   226 QWSLV-MESVVPS-DKGNYTCVVENKYGSIRQTYQLDVLERSSHRPILQAGLPANQTVVIGSDVE 288

  Fly   533 -------------------GVTGSGAAAAGEVYNVP----RNNTPIEIDLPPIAQKTEA-EVEYF 573
                               .|.||.....|:.|...    .|.|.::..| .:...||. |.:|.
 Frog   289 FHCKVYSDAQPHIQWLKHVEVNGSKYGPDGDPYVTVLQSFTNGTEVDTTL-SLKNVTETHEGQYV 352

  Fly   574 TKSDVAIERERAGQWIGNGYQP------------------TMDVLSLL----------------- 603
            .:::..|....|..|: :.|:|                  .:.|:|::                 
 Frog   353 CRANNFIGVAEASFWL-HIYKPASAEPVEKPTTTSSSSTTVLIVVSVITGFILLVIIFVTYRVKV 416

  Fly   604 --DQQIKAPAVARLN---------SLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFI 657
              .:.:.||.|.:::         ||..|:|..|..........|.:..|..|   ..::|...:
 Frog   417 PSKKAMSAPPVHKVSKFPLKRQQVSLESNSSMNSNTPLVRITHLSSSDGTMLA---NVSELGLPL 478

  Fly   658 EPE------KLVLDREIGHGEFGSVHSGWLLRKSGAGEESR----LEVAIKMLSDEHSNK--QEF 710
            :|:      :|.|.:.:|.|.||.|    ::.::...|:.|    :.||:|||.|:.::|  .:.
 Frog   479 DPKWELLRTRLTLGKPLGEGCFGQV----VMAEAIGIEKERPNKPVTVAVKMLKDDATDKDLSDL 539

  Fly   711 LREASVMMRL-EHKCIVRLIGIA--KGEMLMMVQELAPLGSMLQYI-------LDHGHE---ITA 762
            :.|..:|..: :||.|:.|:|..  .|.:.::| |.|..|::.:|:       :|:..:   |.|
 Frog   540 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVLV-EYASKGNLREYLKARRPPGMDYSFDTCKIPA 603

  Fly   763 N----AELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQF 823
            .    .:|...|.|:|.||.||.||..:||||||||:|:|..:..||:|||::|.:. ....|:.
 Frog   604 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDIH-NIDYYKK 667

  Fly   824 TQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQ 888
            |..||.|::|.|||:....|::|.|||||:||.:||.|:||..||..|...:..||:..|.|:.:
 Frog   668 TTNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKLLKEGHRMDK 732

  Fly   889 PNLCPAYIYAVMQSCWKERPKDRPTFVYLTE 919
            |..|...:|.:|:.||...|..||||..|.|
 Frog   733 PANCTHELYMIMRECWHAVPSQRPTFKQLVE 763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430 21/91 (23%)
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786 192/811 (24%)
SH2_Cterm_shark_like 287..395 CDD:198211 20/119 (17%)
PTKc_Syk_like 666..926 CDD:270650 99/277 (36%)
fgfr3XP_012812743.1 Ig <75..128 CDD:472250 13/59 (22%)
Ig strand B 78..82 CDD:409353 1/3 (33%)
Ig strand C 90..94 CDD:409353 1/4 (25%)
Ig strand E 111..115 CDD:409353 1/3 (33%)
IgI_2_FGFR 167..261 CDD:409443 21/138 (15%)
Ig strand A 167..170 CDD:409443 2/28 (7%)
Ig strand A' 178..183 CDD:409443 0/4 (0%)
Ig strand B 187..195 CDD:409443 1/7 (14%)
Ig strand C 201..206 CDD:409443 0/4 (0%)
Ig strand C' 209..211 CDD:409443 0/1 (0%)
Ig strand D 220..223 CDD:409443 0/2 (0%)
Ig strand E 227..232 CDD:409443 1/5 (20%)
Ig strand F 241..248 CDD:409443 0/6 (0%)
Ig strand G 251..261 CDD:409443 4/9 (44%)
IgI_3_FGFR 269..369 CDD:409363 18/101 (18%)
Ig strand A 269..272 CDD:409363 1/2 (50%)
Ig strand A' 276..280 CDD:409363 0/3 (0%)
Ig strand B 288..295 CDD:409363 0/6 (0%)
Ig strand C 299..306 CDD:409363 0/6 (0%)
Ig strand D 321..326 CDD:409363 1/4 (25%)
Ig strand E 336..341 CDD:409363 1/5 (20%)
Ig strand F 349..357 CDD:409363 1/7 (14%)
Ig strand G 360..368 CDD:409363 1/7 (14%)
PTKc_FGFR3 476..809 CDD:173652 102/294 (35%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.