Protein Alignment Shark and jak2

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_001090634.1
• Gene: jak2 / 100036599
• XenbaseID: XB-GENE-483712
• Length: 1129
• Species: Xenopus tropicalis
• Alignment Length: 949
• Identity: 219/949 - (23%)
• Similarity: 352/949 - (37%)
• Gaps: 272/949 - (28%)

  Fly    12 HGNLSRE-AADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDK 75
            ||.:|.| |.::|.|.|.:.|.|::|.|......:.|:                     |||:..
 Frog   399 HGPVSMEFAINKLKKAGNQRGLFILRCSPKEFNKYFLT---------------------FSIERD 442

  Fly    76 VQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELL 140
            ..|:..|.|.|..|......:|  .|.:...::||          .|...:.|.:::. ::|:..
 Frog   443 GVTQYKHCLITKNDNGDYNLSG--AKKSFATLKDL----------LNCYQKETVRSDG-IIFQFR 494

  Fly   141 KCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFG-----CQPLHYAARSKPA 200
            :|.......|:       :|....|:||         .:|:||.:..     .|.:.:..||:..
 Frog   495 RCCPPRPKEKS-------NLIIFRSNED---------SEVSSSPTLQRNNNVNQMVFHKIRSEDL 543

  Fly   201 SFIRTLISAQAN----VQGRNIDNG-YVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDL 260
            .|:..|  .|..    .:|:..:.| |..:|          |.|:||.......|:.|..| |:.
 Frog   544 HFLENL--GQGTFTKIFKGKREELGDYNKIH----------VTEVLLKVLDKTHRSFSESF-FEA 595

  Fly   261 AKEAGQTAVEEFLLNYKL----PPANTTRDQWYHGTLTREEAVAILK--KHAKELLAKQPEVDTS 319
            |....|.:.:..:|||.:    ..:...::...:|:|.     ..||  |:|..::.|. ||...
 Frog   596 ASMMSQLSYKHLILNYGVCVCGDESILVQEYAKYGSLD-----TYLKRNKNAINIMWKL-EVSKQ 654

  Fly   320 GCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHL 384
            ..:.:.:.|.   ..||...:|.   ||..:.:.:..:.||      ..|:.:.|    |.:
 Frog   655 LAWAMHFLED---RNLVHGNVCS---KNILLIREEDRKTGN------PPFIKLSD----PGI--- 700

  Fly   385 IAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPA 449
                                        |...:|:..:..:.  |..||..:....|
 Frog   701 ----------------------------SITVLPKEILLERI--PWVPPECIDNSKH-------- 727

  Fly   450 LTITKKKQKENSSSMFNTL--RLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQA 512
            ||     |..:..|...||  ..:...|.|..::|.||                 |...|...|.
 Frog   728 LT-----QASDKWSFGTTLWEIYSGGDKPLTALDSQRK-----------------LQFYEDRHQL 770

  Fly   513 AAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSD 577
            .||....|:                         |:..:....|.|..|              |.
 Frog   771 PAPKWIELA-------------------------NLINSCMDYEPDFRP--------------SF 796

  Fly   578 VAIERERAGQWIGNGYQPTMDVLSLLD--QQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTP 640
            .||.|:     :.:.:.|..::|:..|  |.:      |:.:.|.:...|.....:
 Frog   797 RAIIRD-----LNSLFTPDYELLAETDFLQNM------RIGAFGFSGGFEDRDPPF--------- 841

  Fly   641 STPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHS 705
                    |...|:|.         :::|.|.||||.   |.|.....:.:...||:|.|  :|:
 Frog   842 --------EERHLKFL---------QQLGKGNFGSVE---LCRYDPLQDNTGEVVAVKKL--QHT 884

  Fly   706 NKQ---EFLREASVMMRLEHKCIVRLIGI---AKGEMLMMVQELAPLGSMLQYILDHGHEITANA 764
            .::   :|.||..::..|:|..|||..|:   |....|.::.|..|.||:..|:..|...:...
 Frog   885 TEEYLRDFEREIEILKSLQHDNIVRYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKDRLDFK- 948

  Fly   765 ELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRW 829
            :|..::|||..||.||..:.::|||||.||||:...::.||.|||:::.|......|:..:.|..
 Frog   949 KLLQYSSQICKGMEYLTIKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGES 1013

  Fly   830 PIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLG----APP-----------YGEISNVDAIKL 879
            ||.||||||.....||.|||||||||.::|:|:..    :||           .|::.....|:|
 Frog  1014 PIFWYAPESLTESKFSVASDVWSFGVVLYELFTYSEKSKSPPSEFMRMIGNDKQGQMIVFHLIEL 1078

  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLT 918
            :.:..|||||..||..||.:|..||......||:|..||
 Frog  1079 LKNKGRLPQPEGCPDEIYRIMNECWNNSISQRPSFKELT 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	21/79 (27%)
		ANKYR	<94..317	CDD:440430	47/238 (20%)
		ANK repeat	124..151	CDD:293786	3/26 (12%)
		ANK repeat	153..184	CDD:293786	6/30 (20%)
		ANK repeat	186..217	CDD:293786	7/39 (18%)
		ANK repeat	220..245	CDD:293786	7/25 (28%)
		SH2_Cterm_shark_like	287..395	CDD:198211	20/109 (18%)
		PTKc_Syk_like	666..926	CDD:270650	98/274 (36%)
jak2	NP_001090634.1	FERM_F1	37..132	CDD:465733
		FERM_F2	140..259	CDD:436450
		FERM_C_JAK2	264..384	CDD:270141
		SH2_Jak2	384..480	CDD:198242	26/113 (23%)
		PTK_Jak2_rpt1	543..804	CDD:270663	71/402 (18%)
		PTKc_Jak2_rpt2	841..1124	CDD:271107	101/309 (33%)