Protein Alignment pie and KMT2B

DIOPT Version :10

• Sequence 1: NP_524740.2
• Gene: pie / 44315
• FlyBaseID: FBgn0005683
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_055542.1
• Gene: KMT2B / 9757
• HGNCID: 15840
• Length: 2715
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 110/525 - (20%)
• Similarity: 163/525 - (31%)
• Gaps: 164/525 - (31%)

  Fly     1 MEDNKELQCLIC-KYSDTDDLVFGEWMIV-RNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIR 63
            :||.:  ||.:| ||.|.|....|..:.: :|...|..|.:.|..:.:....|       |:::.
Human  1575 LEDPR--QCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGS-------LKNVH 1630

  Fly    64 EEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKR 126
            ...|...:.:|..|.|.||::.|  ..|.|.||..|...:..:|:  ...|.:|.|...:.|.|.
Human  1631 AAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQ--DDKKVFCQKHTDLLDGKE 1693

  Fly   127 QLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGYYLRCIWCRSERFR 191
            .:.         |..|..:.:      ||.|...:.|..|       ..:|.....|    ....
Human  1694 IVN---------PDGFDVLRR------VYVDFEGINFKRK-------FLTGLEPDAI----NVLI 1732

  Fly   192 DSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNC---LCPSGRTYNRLSWVILCCSSCAA 253
            .|||:.|:                      ....|..:|   |.|.|...:||.|        :.
Human  1733 GSIRIDSL----------------------GTLSDLSDCEGRLFPIGYQCSRLYW--------ST 1767

  Fly   254 TSAHLKCLVGALRLPKKRERTDFKCSMCLDVERRIAE----GPARTTEETNADGDNQVDGSFYVQ 314
            ..|..:|.              ::|        ||.|    ||........|..:||
Human  1768 VDARRRCW--------------YRC--------RILEYRPWGPREEPAHLEAAEENQ-------- 1802

  Fly   315 KLGPDAATRSLTQTPVFSEE---DESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSP 376
                     ::..:|..|.|   .|........::...|:.::..:  :|.||..      |||.
Human  1803 ---------TIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQ--NLDPPLR------PDSG 1850

  Fly   377 EASPKTSID--------ENHSP--QPIARRDTSDSPQPIAASEI---------PDSPQPTAASEI 422
            .|.|.....        .|:||  :|:........|.|.:.|.:         ||.|.|...|.
Human  1851 SAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSR- 1914

  Fly   423 PDLPQTTAINVNPELTQQTALNTIPHSPQ----PEASFSTQLVSQTFDCPQPQEQAVAKAPNSPS 483
              .|...|....|.......|.|   |||    |..|..|.|...:.:...|     ..||:.|
Human  1915 --RPSPLAPRPPPSRWASPPLKT---SPQLRVPPPTSVVTALTPTSGELAPP-----GPAPSPP- 1968

  Fly   484 LPKED 488
             |.||
Human  1969 -PPED 1972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_524740.2	PHD_SF	9..117	CDD:473978	28/111 (25%)
		PHD_SF	224..>260	CDD:473978	9/38 (24%)
		PRK10263	<265..>493	CDD:236669	53/254 (21%)
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000269|PubMed:22327296	17..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..518
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..771
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..868
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	894..959
		zf-CXXC	958..1005	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1146..1166
		PHD1_KMT2B	1203..1249	CDD:277064
		PHD2_KMT2B	1251..1300	CDD:277066
		PHD3_KMT2B	1337..1393	CDD:277068
		Bromo_ALL-1	1374..1516	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1567
		ePHD_KMT2B	1581..1685	CDD:277164	28/112 (25%)
		FYRN	1733..1780	CDD:461787	15/98 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1806..1978		44/188 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2280..2412
		FYRC	2413..2497	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	2508..2513
		SET_KMT2A_2B	2562..2715	CDD:380947