DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pie and KMT2B

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_055542.1	Gene:	KMT2B / 9757	HGNCID:	15840	Length:	2715	Species:	Homo sapiens

Alignment Length:	525	Identity:	110/525 - (20%)
Similarity:	163/525 - (31%)	Gaps:	164/525 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDNKELQCLIC-KYSDTDDLVFGEWMIV-RNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIR 63
            :||.:  ||.:| ||.|.|....|..:.: :|...|..|.:.|..:.:....|       |:::.
Human  1575 LEDPR--QCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGS-------LKNVH 1630

  Fly    64 EEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKR 126
            ...|...:.:|..|.|.||::.|  ..|.|.||..|...:..:|:  ...|.:|.|...:.|.|.
Human  1631 AAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQ--DDKKVFCQKHTDLLDGKE 1693

  Fly   127 QLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGYYLRCIWCRSERFR 191
            .:.         |..|..:.:      ||.|...:.|..|       ..:|.....|    ....
Human  1694 IVN---------PDGFDVLRR------VYVDFEGINFKRK-------FLTGLEPDAI----NVLI 1732

  Fly   192 DSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNC---LCPSGRTYNRLSWVILCCSSCAA 253
            .|||:.|:                      ....|..:|   |.|.|...:||.|        :.
Human  1733 GSIRIDSL----------------------GTLSDLSDCEGRLFPIGYQCSRLYW--------ST 1767

  Fly   254 TSAHLKCLVGALRLPKKRERTDFKCSMCLDVERRIAE----GPARTTEETNADGDNQVDGSFYVQ 314
            ..|..:|.              ::|        ||.|    ||........|..:||
Human  1768 VDARRRCW--------------YRC--------RILEYRPWGPREEPAHLEAAEENQ-------- 1802

  Fly   315 KLGPDAATRSLTQTPVFSEE---DESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSP 376
                     ::..:|..|.|   .|........::...|:.::..:  :|.||..      |||.
Human  1803 ---------TIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQ--NLDPPLR------PDSG 1850

  Fly   377 EASPKTSID--------ENHSP--QPIARRDTSDSPQPIAASEI---------PDSPQPTAASEI 422
            .|.|.....        .|:||  :|:........|.|.:.|.:         ||.|.|...|.
Human  1851 SAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSR- 1914

  Fly   423 PDLPQTTAINVNPELTQQTALNTIPHSPQ----PEASFSTQLVSQTFDCPQPQEQAVAKAPNSPS 483
              .|...|....|.......|.|   |||    |..|..|.|...:.:...|     ..||:.|
Human  1915 --RPSPLAPRPPPSRWASPPLKT---SPQLRVPPPTSVVTALTPTSGELAPP-----GPAPSPP- 1968

  Fly   484 LPKED 488
             |.||
Human  1969 -PPED 1972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	28/111 (25%)
		PHD_SF	224..>260	CDD:304600	9/38 (24%)
		PARM	318..>491	CDD:293666	44/197 (22%)
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000269\|PubMed:22327296	17..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..302
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..868
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..959
		zf-CXXC	958..1005	CDD:251032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1146..1166
		PHD1_KMT2B	1203..1249	CDD:277064
		PHD2_KMT2B	1251..1300	CDD:277066
		PHD3_KMT2B	1337..1393	CDD:277068
		Bromo_ALL-1	1374..1516	CDD:99925
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1567
		ePHD_KMT2B	1581..1685	CDD:277164	28/112 (25%)
		FYRN	1734..1780	CDD:283589	15/97 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1806..1978		44/188 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2280..2412
		FYRC	2413..2497	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	2508..2513
		SET	<2559..2715	CDD:225491
		SET	2577..2697	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q03164	2652..2653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810