DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and TCF20

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001365347.1	Gene:	TCF20 / 6942	HGNCID:	11631	Length:	1960	Species:	Homo sapiens

Alignment Length:	246	Identity:	49/246 - (19%)
Similarity:	79/246 - (32%)	Gaps:	89/246 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 DVERRIAE------GPA-----------RTTEETNADGDNQVDGSFYVQ-----KLGPDAATRSL 325
            |:|:|..|      .||           |::||.....|::|....:.:     |..|.|.|.:.
Human  1404 DIEKRKGEVASDLVSPANQELHVEKPLPRSSEEWRGSVDDKVKTETHAETVTAGKEPPGAMTSTT 1468

  Fly   326 TQTPVFSE-EDESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKTSIDENH- 388
            :|.|..:: ..:........:||...|:         .||...:      :|||:||....||.
Human  1469 SQKPGSNQGRPDGSLGGTAPLIFPDSKN---------VPPVGIL------APEANPKAEEKENDT 1518

  Fly   389 ---SP------------------QPIARRDTSDSPQPIAASEIPDSPQPTAASEIPDLPQTTA-- 430
               ||                  :||.    |.:.|.......|..|||      |.:|:.:|
Human  1519 VTISPKQEGFPPKGYFPSGKKKGRPIG----SVNKQKKQQQPPPPPPQP------PQIPEGSADG 1573

  Fly   431 -----------------INVNPELTQQTALNTIPHSPQPEASFSTQLVSQT 464
                             .......|:|......|..|:.:..::||.:.:|
Human  1574 EPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLDKT 1624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600
		PHD_SF	224..>260	CDD:304600
		PARM	318..>491	CDD:293666	37/189 (20%)
TCF20	NP_001365347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..287
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..392
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..748
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..1037
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1142
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1162..1285
		Leucine-zipper	1170..1191
		Nuclear localization signal. /evidence=ECO:0000250	1254..1268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1303..1331
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1384..1607		44/227 (19%)
		Nuclear localization signal. /evidence=ECO:0000250	1576..1600		1/23 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1660..1683
		ePHD_TCF20	1705..1932	CDD:277169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1732..1839
		Nuclear localization signal. /evidence=ECO:0000250	1785..1792
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1939..1960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900