Protein Alignment ome and DPP4

DIOPT Version :10

• Sequence 1: NP_001097606.1
• Gene: ome / 44297
• FlyBaseID: FBgn0259175
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_001926.2
• Gene: DPP4 / 1803
• HGNCID: 3009
• Length: 766
• Species: Homo sapiens
• Alignment Length: 817
• Identity: 263/817 - (32%)
• Similarity: 411/817 - (50%)
• Gaps: 110/817 - (13%)

  Fly   267 RIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGN 331
            :::|.::.....|.::...:|.:    .|..||:.::|.....|.|.|......|.::..|.:.:
Human     6 KVLLGLLGAAALVTIITVPVVLL----NKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDH 66

  Fly   332 SLIYKENTSIMEFDAKTGERSILLEDAQ-----HYVL-YEKSADGEFLLLAKNYKKNFRYSFLAE 390
            ..:||:..:|:.|:|:.|..|:.||::.     |.:. |..|.||:|:||..||.|.:|:|:.|.
Human    67 EYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTAS 131

  Fly   391 YDLYNLNTKEFI-QLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYK-ESAL-AQEIALTSDEQA 452
            ||:|:||.::.| :..|.|...:   |.|||||:.|...::.::|.| |..| :..|..|..|..
Human   132 YDIYDLNKRQLITEERIPNNTQW---VTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDI 193

  Fly   453 GILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVI 517
             |.|||.||||||||||:..|.|::|:||.||:.:|:|:...||.:.:|.|..   .|||....:
Human   194 -IYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDES---LQYPKTVRV 254

  Fly   518 AYPKAGSSNPRVELVMV--DLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMN 580
            .|||||:.||.|:..:|  |...:|.....:.:....|.|  ..|:.:..|:|...:.:...|:.
Human   255 PYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASML--IGDHYLCDVTWATQERISLQWLR 317

  Fly   581 RIQNAAYVVTFDGLNRKVIYSAE---------------SKTGWVDLY--TAPFRNRNGSRLAFVL 628
            ||||.:.:...|       |...               |.||||..:  :.|....:|:....::
Human   318 RIQNYSVMDICD-------YDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKII 375

  Fly   629 PH-NNYKHV--------QLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANT-EDH 683
            .: ..|:|:        .....|..:.|...:|.||               :|.::|.:|. :..
Human   376 SNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALT---------------SDYLYYISNEYKGM 425

  Fly   684 PEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFN-DNNHIVITSLGPGIP--TTHIYEW 745
            |...:||.|:........||:|.|   ...:..|:|.:|: :..:..:...|||:|  |.|
Human   426 PGGRNLYKIQLSDYTKVTCLSCEL---NPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLH---- 483

  Fly   746 KYENSQVVISKVLD-----WETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQ--LPPNLDT 803
                     |.|.|     .|.|.:|...|:.|.:||.|:..:.::   :.|...|  |||:.|.
Human   484 ---------SSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILN---ETKFWYQMILPPHFDK 536

  Fly   804 SGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLG 868
            |  .|||:|:|||.||.|......:.::|.|||:|.:::|.|..||||||.:|:.::|||..:||
Human   537 S--KKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLG 599

  Fly   869 TVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYY 933
            |.|:.|||...::.|.: .::|...:.|||||||||..:|.|.:... ||||..::|||:.|.||
Human   600 TFEVEDQIEAARQFSKM-GFVDNKRIAIWGWSYGGYVTSMVLGSGSG-VFKCGIAVAPVSRWEYY 662

  Fly   934 DSIYTERYMGL--PNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQD 996
            ||:||||||||  |..|...|.||.:.:.|...:..:|||:|||.|||||:||:..::|.|....
Human   663 DSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVG 727

  Fly   997 ILFKQISYADEDHGL--SNVRPHLYHSLDRFFGECFA 1031
            :.|:.:.|.|||||:  |....|:|..:..|..:||:
Human   728 VDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFS 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:395744	119/406 (29%)
		Peptidase_S9	828..1033	CDD:459761	91/208 (44%)
DPP4	NP_001926.2	DPPIV_rep	38..58	CDD:465875	5/19 (26%)
		DPPIV_N	108..478	CDD:395744	118/403 (29%)
		Peptidase_S9	559..763	CDD:459761	89/205 (43%)