Protein Alignment SoxN and SOX2

DIOPT Version :10

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_003097.1
• Gene: SOX2 / 6657
• HGNCID: 11195
• Length: 317
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 159/451 - (35%)
• Similarity: 197/451 - (43%)
• Gaps: 145/451 - (32%)

  Fly   131 HQQHTQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATANKNQQHA-DRVKRPMNAFMVWSRGQR 194
            :...|:.:..|.||           |.|....|:.:|.|..||::: ||||||||||||||||||
Human     3 NMMETELKPPGPQQ-----------TSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQR 56

  Fly   195 RKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLTK 259
            ||||.:|||||||||||||||:||.|||:||||||||||||||:|||||||||||||||||||.|
Human    57 RKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMK 121

  Fly   260 TKEKYPM-GGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLNGSGGSAAAAAAAAAAAAQQARQD 323
             |:||.: |||:                     .||.|...:|.|      ..|...|....|.|
Human   122 -KDKYTLPGGLL---------------------APGGNSMASGVG------VGAGLGAGVNQRMD 158

  Fly   324 MYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQ-----RYDMGHMYNNGYAMYQTVSGG 383
            .|.  ..||:....|.|..|..|..  |...:..|.|||     |||:..:..|.....||...|
Human   159 SYA--HMNGWSNGSYSMMQDQLGYP--QHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNG 219

  Fly   384 QTSP-YGSSLQQPGSPSPYGGSSLQQQPGSPTPYGGGGGGGGQVSCQSHSPSDSSIKSEPVSPSP 447
              || |..|..|.|:|    |.:|              |..|.|           :||| .|.||
Human   220 --SPTYSMSYSQQGTP----GMAL--------------GSMGSV-----------VKSE-ASSSP 252

  Fly   448 SAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELNHLMNMYHLPDEQRHLLHYQTDS 512
            ..:.                 ||:.:.|...|       |:|..:::|| ||
Human   253 PVVT-----------------SSSHSRAPCQA-------GDLRDMISMY-LP------------- 279

  Fly   513 PDLQQQHQSMQQQQQHLPQQ-HLSQQHQQIPQQHHTMQQQQQQHHLQHQQSLRAMAPLAHM 572
                    ..:..:...|.: |:||.:|..|..               ..::....||:||
Human   280 --------GAEVPEPAAPSRLHMSQHYQSGPVP---------------GTAINGTLPLSHM 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	HMG-box_SoxB	177..252	CDD:438790	68/74 (92%)
SOX2	NP_003097.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		14/50 (28%)
		HMG-box_SoxB	39..118	CDD:438790	72/78 (92%)
		SOXp	110..200	CDD:463537	38/121 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..266		10/51 (20%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P41225	272..280		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..317		4/34 (12%)