Protein Alignment SoxN and sox17a

DIOPT Version :10

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_989425.1
• Gene: sox17a / 395066
• XenbaseID: XB-GENE-484295
• Length: 383
• Species: Xenopus tropicalis
• Alignment Length: 557
• Identity: 132/557 - (23%)
• Similarity: 198/557 - (35%)
• Gaps: 200/557 - (35%)

  Fly   125 MTSPVSHQQHTQQQQHGQQQHLGAGSALSSLTG-------------GSSNNNNNSATANKNQQHA 176
            |:||........|.|       |..|....:||             |.....:::.:||...:..
 Frog     1 MSSPDGGYASDDQNQ-------GKCSVPIMMTGLGQCQWAEPMNSLGEGKLKSDAGSANSRGKAE 58

  Fly   177 DRVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMK 241
            .|::|||||||||::.:|:::|..||.:||:|:||.||..||.|:.:|||||::||:|||..||:
 Frog    59 ARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQ 123

  Fly   242 EHPDYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLNGSGGSA 306
            :||:|||||||: |.:.:.|
 Frog   124 DHPNYKYRPRRR-KQVKRMK--------------------------------------------- 142

  Fly   307 AAAAAAAAAAAQQARQDMYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDMGHM-- 369
                          |.|            .|:|..|:|..:|...|.             |.|
 Frog   143 --------------RAD------------TGFMHMAEPPESAVLGTD-------------GRMCL 168

  Fly   370 --YNNGYAMYQTVSGGQTSPYGSSLQQPGSPSP-YGGSSLQQQPGSPTPYGGGGGGGGQVSCQSH 431
              ::.|| ..||....|. |.||..::|.:.:| |.|.||      |||              ..
 Frog   169 ESFSLGY-HEQTYPHSQL-PQGSHYREPQAMAPHYDGYSL------PTP--------------ES 211

  Fly   432 SPSDSSIKSEPV----SPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAG-GGELNH 491
            ||.|.: :::||    .|......:..:.|.:..|   ::.|.|:........|...| |..:..
 Frog   212 SPLDLA-EADPVFFTSPPQDECQMMPYSYNASYTH---QQNSGASMLVRQMPQAEQMGQGSPVQG 272

  Fly   492 LMNMYHLPDEQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQHLSQQHQQIPQ--QHHTMQQQQQQ 554
            :|..                     |....|...|.:||.   |.:|.|:||  |:....:.||.
 Frog   273 MMGC---------------------QSSPQMYYGQMYLPG---SARHHQLPQAGQNSPPPEAQQM 313

  Fly   555 HHLQHQQSLRAMAPLAHM-XEMASAYGAAGSSVSVSPPLPPYMPTAPQQQQQQQQQQQQLLNGRP 618
            ....|.|.:..:|.:...  |...:| .|.|.:.:.                        .:|:.
 Frog   314 GRADHIQQVDMLAEVDRTEFEQYLSY-VAKSDLGMH------------------------YHGQE 353

  Fly   619 SPTASGSSGGRSSAHSSGHTAAHSPALAAAYQLTPSA 655
            |...:..:|..||..|...||.:       |...|||
 Frog   354 SVVPTADNGPISSVLSDASTAVY-------YCNYPSA 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	HMG-box_SoxB	177..252	CDD:438790	43/74 (58%)
sox17a	NP_989425.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..58		3/20 (15%)
		HMG-box_SoxF_SOX17	55..135	CDD:438850	44/79 (56%)
		Sox17_18_mid	191..239	CDD:463454	15/68 (22%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q9H6I2	331..339		1/7 (14%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250|UniProtKB:Q3KQ35	332..337		1/4 (25%)